Role of connexins and pannexins during ontogeny, regeneration, and pathologies of bone

Lilian Plotkin, Dale W. Laird, Joelle Amedee

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Electron micrographs revealed the presence of gap junctions in osteoblastic cells over 40 years ago. These intercellular channels formed from connexins are present in bone forming osteoblasts, bone resorbing osteoclasts, and osteocytes (mature osteoblasts embedded in the mineralized bone matrix). More recently, genetic and pharmacologic studies revealed the role of connexins, and in particular Cx43, in the differentiation and function of all bone types. Furthermore, mutations in the gene encoding Cx43 were found to be causally linked to oculodentodigital dysplasia, a condition that results in an abnormal skeleton. Pannexins, molecules with similar structure and single-membrane channel forming potential as connexins when organized as hemichannels, are also expressed in osteoblastic cells. The function of pannexins in bone and cartilage is beginning to be uncovered, but more research is needed to determine the role of pannexins in bone development, adult bone mass and skeletal homeostasis. We describe here the current knowledge on the role of connexins and pannexins on skeletal health and disease.

Original languageEnglish (US)
Article number19
JournalBMC cell biology [electronic resource]
Volume17
Issue number1
DOIs
StatePublished - May 24 2016

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Connexins
Bone Regeneration
Pathology
Bone and Bones
Connexin 43
Osteoblasts
Osteocytes
Bone Matrix
Gap Junctions
Bone Development
Osteoclasts
Ion Channels
Skeleton
Cartilage
Homeostasis
Electrons
Mutation
Health
Research
Genes

ASJC Scopus subject areas

  • Cell Biology

Cite this

Role of connexins and pannexins during ontogeny, regeneration, and pathologies of bone. / Plotkin, Lilian; Laird, Dale W.; Amedee, Joelle.

In: BMC cell biology [electronic resource], Vol. 17, No. 1, 19, 24.05.2016.

Research output: Contribution to journalArticle

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