Role of corticotropin-releasing factor and urocortin within the basolateral amygdala of rats in anxiety and panic responses

Tammy J. Sajdyk, Douglas A. Schober, Donald R. Gehlert, Anantha Shekhar

Research output: Contribution to journalArticle

160 Citations (Scopus)

Abstract

The amygdala is a critical temporal lobe structure involved in the expression of anxiety and stress responses. The basolateral nucleus (BLA) of the amygdala in particular, may play a key role in anxiety. Furthermore, corticotropin-releasing factor (CRF), a 41 amino acid peptide, has been strongly implicated in the regulation of stress and anxiety responses. Centrally administered CRF has been shown to increase the anxiety-like behaviors of rodents in several animal models. A recently cloned related peptide, Urocortin (Ucn), appears to have similar affinity for the CRF1 receptor, but higher affinity at the CRF2 receptor. When microinjected into the BLA, we found Ucn was substantially more potent than CRF in producing anxiogenic-like behavior as assessed in the social interaction test. Furthermore, repetitive administration of subthreshold doses of Ucn and CRF resulted in 'priming'. Once primed, these animals exhibited behavioral and cardiovascular responses to intravenous sodium lactate, a panicogenic agent in susceptible human patients. These results suggest central CRF and Ucn play a role in generating anxiety which may be similar to that seen in pathological conditions such as panic disorder.

Original languageEnglish
Pages (from-to)207-215
Number of pages9
JournalBehavioural Brain Research
Volume100
Issue number1-2
DOIs
StatePublished - Apr 1 1999

Fingerprint

Urocortins
Panic
Corticotropin-Releasing Hormone
Anxiety
Amygdala
Sodium Lactate
Peptides
Panic Disorder
Temporal Lobe
Interpersonal Relations
Rodentia
Animal Models
Basolateral Nuclear Complex
Amino Acids

Keywords

  • Anxiety
  • Corticotropin-releasing factor
  • Panic
  • Social interaction
  • Sodium lactate
  • Urocortin

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Role of corticotropin-releasing factor and urocortin within the basolateral amygdala of rats in anxiety and panic responses. / Sajdyk, Tammy J.; Schober, Douglas A.; Gehlert, Donald R.; Shekhar, Anantha.

In: Behavioural Brain Research, Vol. 100, No. 1-2, 01.04.1999, p. 207-215.

Research output: Contribution to journalArticle

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