Role of cytokines in the pathophysiology of acute graft-versus-host disease (GVHD)- are serum/plasma cytokines potential biomarkers for diagnosis of acute GVHD following allogeneic hematopoietic cell transplantation (Allo-HCT)?

Tomomi Toubai, Junji Tanaka, Sophie Paczesny, Yusuke Shono, Pavan Reddy, Masahiro Imamura

Research output: Contribution to journalReview article

24 Scopus citations

Abstract

Due to the advent of less-toxic reduced intensity conditioning regimens (RIT), allogeneic hematopoietic cell transplantation (allo-HCT) is currently widely used to treat chemotherapy-resistant hematological diseases, particularly in older patients,which are the fastest growing group of patients receiving allo-HCT. However, graft-versus-host disease (GVHD) is still the major complication after allo-HCT, causing immune deficiency, infection, organ damage, and occasionally patient death. Mortality from GVHD is in part attributed to the difficulty in making accurate diagnosis and determining the optimal timing for appropriate treatment. The diagnosis of acute GVHD is dependent on clinical features and is sometimes indistinguishable from other causes and requires invasive procedures. Therefore, non-invasive, diagnostic and predictive monitoring tools, such as plasma/serum biomarkers, are needed. Determination of the roles of cytokines in the physiopathology of acute GVHD has provided an explanation for many preclinical and clinical observations. However, measurement of a single cytokine lacks specificity for GVHD diagnosis. Therefore, comprehensive assessment of plasma/serum cytokine concentrations is required to identify a panel of biomarkers with good specificity and sensitivity for GVHD. In this review, we summarize the roles of individual cytokines in the pathophysiology of acute GVHD and discuss the possibility of cytokines as biomarkers of acute GVHD after allo-HCT.

Original languageEnglish (US)
Pages (from-to)229-239
Number of pages11
JournalCurrent Stem Cell Research and Therapy
Volume7
Issue number3
DOIs
StatePublished - May 2012

Keywords

  • Allogeneic hematopoietic stem cell transplantation (allo-HCT)
  • Biomarker
  • Cytokine
  • Graft-versus-host disease (GVHD)

ASJC Scopus subject areas

  • Medicine (miscellaneous)

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