Role of eIF3a in regulating cell cycle progression

Zizheng Dong, Zhaoqian Liu, Ping Cui, Roxana Pincheira, Youyun Yang, Jianguo Liu, Jian-Ting Zhang

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Translational control is an essential process in regulation of gene expression, which occurs at the initiation step performed by a number of translation initiation factor complexes. eIF3a (eIF3 p170) is the largest subunit of the eIF3 complex. eIF3a has been suggested to play roles in regulating translation of a subset of mRNAs and in regulating cell cycle progression and cell proliferation. In this study, we examined the expression profile of eIF3a in cell cycle and its role in cell cycle progression. We found that eIF3a expression oscillated with cell cycle and peaked in S phase. Reducing eIF3a expression also reduced cell proliferation rate by elongating cell cycle but did not change the cell cycle distribution. However, eIF3a appears to play an important role in cellular responses to external cell cycle modulators likely by affecting synthesis of target proteins of these modulators.

Original languageEnglish
Pages (from-to)1889-1894
Number of pages6
JournalExperimental Cell Research
Volume315
Issue number11
DOIs
StatePublished - Jul 1 2009

Fingerprint

Cell Cycle
Cell Proliferation
Peptide Initiation Factors
Gene Expression Regulation
S Phase
Messenger RNA
Proteins

Keywords

  • Cell cycle
  • eIF3 p170
  • eIF3a
  • Modulators
  • Translational control

ASJC Scopus subject areas

  • Cell Biology

Cite this

Dong, Z., Liu, Z., Cui, P., Pincheira, R., Yang, Y., Liu, J., & Zhang, J-T. (2009). Role of eIF3a in regulating cell cycle progression. Experimental Cell Research, 315(11), 1889-1894. https://doi.org/10.1016/j.yexcr.2009.03.009

Role of eIF3a in regulating cell cycle progression. / Dong, Zizheng; Liu, Zhaoqian; Cui, Ping; Pincheira, Roxana; Yang, Youyun; Liu, Jianguo; Zhang, Jian-Ting.

In: Experimental Cell Research, Vol. 315, No. 11, 01.07.2009, p. 1889-1894.

Research output: Contribution to journalArticle

Dong, Z, Liu, Z, Cui, P, Pincheira, R, Yang, Y, Liu, J & Zhang, J-T 2009, 'Role of eIF3a in regulating cell cycle progression', Experimental Cell Research, vol. 315, no. 11, pp. 1889-1894. https://doi.org/10.1016/j.yexcr.2009.03.009
Dong Z, Liu Z, Cui P, Pincheira R, Yang Y, Liu J et al. Role of eIF3a in regulating cell cycle progression. Experimental Cell Research. 2009 Jul 1;315(11):1889-1894. https://doi.org/10.1016/j.yexcr.2009.03.009
Dong, Zizheng ; Liu, Zhaoqian ; Cui, Ping ; Pincheira, Roxana ; Yang, Youyun ; Liu, Jianguo ; Zhang, Jian-Ting. / Role of eIF3a in regulating cell cycle progression. In: Experimental Cell Research. 2009 ; Vol. 315, No. 11. pp. 1889-1894.
@article{7b7d35d4f65b4315a073882f2677e13b,
title = "Role of eIF3a in regulating cell cycle progression",
abstract = "Translational control is an essential process in regulation of gene expression, which occurs at the initiation step performed by a number of translation initiation factor complexes. eIF3a (eIF3 p170) is the largest subunit of the eIF3 complex. eIF3a has been suggested to play roles in regulating translation of a subset of mRNAs and in regulating cell cycle progression and cell proliferation. In this study, we examined the expression profile of eIF3a in cell cycle and its role in cell cycle progression. We found that eIF3a expression oscillated with cell cycle and peaked in S phase. Reducing eIF3a expression also reduced cell proliferation rate by elongating cell cycle but did not change the cell cycle distribution. However, eIF3a appears to play an important role in cellular responses to external cell cycle modulators likely by affecting synthesis of target proteins of these modulators.",
keywords = "Cell cycle, eIF3 p170, eIF3a, Modulators, Translational control",
author = "Zizheng Dong and Zhaoqian Liu and Ping Cui and Roxana Pincheira and Youyun Yang and Jianguo Liu and Jian-Ting Zhang",
year = "2009",
month = "7",
day = "1",
doi = "10.1016/j.yexcr.2009.03.009",
language = "English",
volume = "315",
pages = "1889--1894",
journal = "Experimental Cell Research",
issn = "0014-4827",
publisher = "Academic Press Inc.",
number = "11",

}

TY - JOUR

T1 - Role of eIF3a in regulating cell cycle progression

AU - Dong, Zizheng

AU - Liu, Zhaoqian

AU - Cui, Ping

AU - Pincheira, Roxana

AU - Yang, Youyun

AU - Liu, Jianguo

AU - Zhang, Jian-Ting

PY - 2009/7/1

Y1 - 2009/7/1

N2 - Translational control is an essential process in regulation of gene expression, which occurs at the initiation step performed by a number of translation initiation factor complexes. eIF3a (eIF3 p170) is the largest subunit of the eIF3 complex. eIF3a has been suggested to play roles in regulating translation of a subset of mRNAs and in regulating cell cycle progression and cell proliferation. In this study, we examined the expression profile of eIF3a in cell cycle and its role in cell cycle progression. We found that eIF3a expression oscillated with cell cycle and peaked in S phase. Reducing eIF3a expression also reduced cell proliferation rate by elongating cell cycle but did not change the cell cycle distribution. However, eIF3a appears to play an important role in cellular responses to external cell cycle modulators likely by affecting synthesis of target proteins of these modulators.

AB - Translational control is an essential process in regulation of gene expression, which occurs at the initiation step performed by a number of translation initiation factor complexes. eIF3a (eIF3 p170) is the largest subunit of the eIF3 complex. eIF3a has been suggested to play roles in regulating translation of a subset of mRNAs and in regulating cell cycle progression and cell proliferation. In this study, we examined the expression profile of eIF3a in cell cycle and its role in cell cycle progression. We found that eIF3a expression oscillated with cell cycle and peaked in S phase. Reducing eIF3a expression also reduced cell proliferation rate by elongating cell cycle but did not change the cell cycle distribution. However, eIF3a appears to play an important role in cellular responses to external cell cycle modulators likely by affecting synthesis of target proteins of these modulators.

KW - Cell cycle

KW - eIF3 p170

KW - eIF3a

KW - Modulators

KW - Translational control

UR - http://www.scopus.com/inward/record.url?scp=67349152700&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67349152700&partnerID=8YFLogxK

U2 - 10.1016/j.yexcr.2009.03.009

DO - 10.1016/j.yexcr.2009.03.009

M3 - Article

C2 - 19327350

AN - SCOPUS:67349152700

VL - 315

SP - 1889

EP - 1894

JO - Experimental Cell Research

JF - Experimental Cell Research

SN - 0014-4827

IS - 11

ER -