Role of fatty acid synthase in gemcitabine and radiation resistance of pancreatic cancers

Youyun Yang, Hailan Liu, Zhaomin Li, Zijin Zhao, Michelle Yip-Schneider, Qipeng Fan, C. Max Schmidt, E. Gabriela Chiorean, Jingwu Xie, Liang Cheng, Jey Hsin Chen, Jian Ting Zhang

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

Human fatty acid synthase (FASN) is a homo-dimeric protein with multi-enzymatic activity responsible for the synthesis of palmitate. FASN expression has been found to be up-regulated in multiple types of human cancers and its expression correlates with poor prognosis possibly by causing treatment resistance. In this study, we tested if FASN expression is up-regulated in human pancreatic cancers and if its higher expression level in pancreatic cancers causes intrinsic resistance to gemcitabine and radiation. We found that FASN expression is significantly up-regulated in human pancreatic cancer tissues without any correlation to age, sex, race, and tumor stage. Knocking down or over-expressing FASN significantly down- or up-regulate resistance of pancreatic cancer cell lines to both gemcitabine and radiation treatments. These findings imply that the elevated FASN expression in pancreatic cancers may contribute to unsuccessful treatments of pancreatic cancers by causing intrinsic resistance to both chemotherapy and radiation therapy.

Original languageEnglish (US)
Pages (from-to)89-98
Number of pages10
JournalInternational Journal of Biochemistry and Molecular Biology
Volume2
Issue number1
StatePublished - 2011

Keywords

  • Gemcitabine
  • Human fatty acid synthase (FASN)
  • Palmitate
  • Pancreatic cancers
  • Radiation treatments
  • Treatment resistance

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry

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