Role of IFN-γ responsiveness in CD8 T cell-mediated viral clearance and demyelination in coronavirus-infected mice

Steven P. Templeton, Stanley Perlman

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Immunocompetent, but not RAG1-/- mice infected with MHV-JHM develop demyelination. Transferred CD8 T cell-enriched splenocytes reconstitute demyelination, and this ability is dependent on donor IFN-γ. We used IFN-γR1-/- mice to examine the target of IFN-γ in CD8 T cell-mediated demyelination. In IFN-γR1-/-RAG1-/- recipients, demyelination is decreased, but not eliminated, while viral titers are significantly increased when compared to IFN-γR1+/+RAG1-/- recipients. IFN-γR1-/- CD8 T cells retain virus-specific effector function regardless of IFN-γR1 expression. Although IFN-γR1 responsiveness is critical for maximal demyelination, increased levels of infectious virus coupled with adoptive transfer of CD8 T cells may result in myelin destruction independent of IFN-γR1 expression.

Original languageEnglish (US)
Pages (from-to)18-26
Number of pages9
JournalJournal of Neuroimmunology
Volume194
Issue number1-2
DOIs
StatePublished - Feb 1 2008

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Keywords

  • CD8 T cells
  • Demyelination
  • IFN-gamma
  • Viral infection

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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