Role of interleukins, IGF and stem cells in BPH

Ian D. McLaren, Travis Jerde, Wade Bushman

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The condition known as benign prostatic hyperplasia may be defined as a benign enlargement of the prostate gland resulting from a proliferation of both benign epithelial and stromal elements. It might also be defined clinically as a constellation of lower urinary tract symptoms (LUTSs) in aging men. The purpose of this review is to consider the ways in which inflammatory cytokines belonging to the interleukin family, members of the IFG family, and stem cells may contribute to the development and progression of BPH-LUTS. This might occur in three mechanisms: One, interleukin signaling, IFG signaling and stem cells may contribute to reactivation of developmental growth mechanisms in the adult prostate leading to tissue growth. Two, given that epidemiologic studies indicate an increased incidence of BPH-LUTS in association with obesity and diabetes, IFG signaling may provide the mechanistic basis for the effect of diabetes and obesity on prostate growth. Three, expression of interleukins in association with inflammation in the prostate may induce sensitization of afferent fibers innervating the prostate and result in increased sensitivity to pain and noxious sensations in the prostate and bladder and heightened sensitivity to bladder filling.

Original languageEnglish
Pages (from-to)237-243
Number of pages7
JournalDifferentiation
Volume82
Issue number4-5
DOIs
StatePublished - Nov 2011

Fingerprint

Interleukins
Prostate
Stem Cells
Lower Urinary Tract Symptoms
Urinary Bladder
Growth
Obesity
Prostatic Hyperplasia
Epidemiologic Studies
Cytokines
Inflammation
Pain
Incidence

Keywords

  • Benign prostate hyperplasia
  • Inflammation
  • Insulin-like growth factor
  • Interleukins
  • Sensitization

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology
  • Molecular Biology
  • Cancer Research

Cite this

Role of interleukins, IGF and stem cells in BPH. / McLaren, Ian D.; Jerde, Travis; Bushman, Wade.

In: Differentiation, Vol. 82, No. 4-5, 11.2011, p. 237-243.

Research output: Contribution to journalArticle

McLaren, Ian D. ; Jerde, Travis ; Bushman, Wade. / Role of interleukins, IGF and stem cells in BPH. In: Differentiation. 2011 ; Vol. 82, No. 4-5. pp. 237-243.
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