Role of medial hypothalamic orexin system in panic, phobia and hypertension

Aline R. Abreu, Andrei I. Molosh, Philip Johnson, Anantha Shekhar

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Orexin has been implicated in a number of physiological functions, including arousal, regulation of sleep, energy metabolism, appetitive behaviors, stress, anxiety, fear, panic, and cardiovascular control. In this review, we will highlight research focused on orexin system in the medial hypothalamic regions of perifornical (PeF) and dorsomedial hypothalamus (DMH), and describe the role of this hypothalamic neuropeptide in the behavioral expression of panic and consequent fear and avoidance responses, as well as sympathetic regulation and possible development of chronic hypertension. We will also outline recent data highlighting the clinical potential of single and dual orexin receptor antagonists for neuropsychiatric conditions including panic, phobia, and cardiovascular conditions, such as in hypertension.

Original languageEnglish (US)
JournalBrain Research
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Panic
Phobic Disorders
Hypertension
Fear
Appetitive Behavior
Arousal
Neuropeptides
Energy Metabolism
Hypothalamus
Sleep
Anxiety
Research

Keywords

  • Anxiety
  • Fear
  • Hypertension
  • Orexin system
  • Panic
  • Sympathetic system

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

Role of medial hypothalamic orexin system in panic, phobia and hypertension. / Abreu, Aline R.; Molosh, Andrei I.; Johnson, Philip; Shekhar, Anantha.

In: Brain Research, 01.01.2018.

Research output: Contribution to journalArticle

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