Role of medial hypothalamic orexin system in panic, phobia and hypertension

Aline R. Abreu, Andrei I. Molosh, Philip L. Johnson, Anantha Shekhar

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Orexin has been implicated in a number of physiological functions, including arousal, regulation of sleep, energy metabolism, appetitive behaviors, stress, anxiety, fear, panic, and cardiovascular control. In this review, we will highlight research focused on orexin system in the medial hypothalamic regions of perifornical (PeF) and dorsomedial hypothalamus (DMH), and describe the role of this hypothalamic neuropeptide in the behavioral expression of panic and consequent fear and avoidance responses, as well as sympathetic regulation and possible development of chronic hypertension. We will also outline recent data highlighting the clinical potential of single and dual orexin receptor antagonists for neuropsychiatric conditions including panic, phobia, and cardiovascular conditions, such as in hypertension.

Original languageEnglish (US)
Article number145942
JournalBrain research
StatePublished - Mar 15 2020


  • Anxiety
  • Fear
  • Hypertension
  • Orexin system
  • Panic
  • Sympathetic system

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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