Role of norepinephrine in substance abuse

Susan L. Broom, Bryan Yamamoto

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Introduction: defining substance abuse Drug abuse is a serious medical and social problem affecting millions of people each year. Substance abuse is usually defined as the misuse of drugs, including taking a drug for purposes other than those prescribed or intended. Dependent or addicted individuals engage in compulsive drug seeking and drug taking despite the consequences to self and others. A recent national survey (in the US) on drug abuse estimated 16.6 million individuals classified as substance abuser and/or dependent, with 1.1 million seeking treatment for substance abuse disorders. Both conditions are recognized for their deleterious consequences to individuals as well as society. Therefore, the primary goal of clinicians is to optimize therapies for maladaptive drug-taking behaviors. This chapter provides an overview of the role of noradrenergic mechanisms involved in the development and maintenance of substance abuse, as well as the integration of the mechanisms mediating the potential adverse consequences of maladaptive drug-taking behavior (i.e., tolerance, dependence, and withdrawal). A wide array of commonly abused substances is discussed. This chapter focuses on the stimulants (i.e., amphetamine and cocaine), but also includes opiates, alcohol, and nicotine. Although some studies to date do not support the clinical efficacy of noradrenergic-based therapies for the treatment of stimulant abuse, others demonstrate a therapeutic potential of noradrenergic compounds for their ability to alleviate the adverse consequences of other abused drugs such as nicotine and opiates. A substantial literature implicates the role of dopamine in the subjective “rewarding” properties of abused drugs (as defined below).

Original languageEnglish (US)
Title of host publicationBrain Norepinephrine: Neurobiology and Therapeutics
PublisherCambridge University Press
Pages610-627
Number of pages18
ISBN (Electronic)9780511544156
ISBN (Print)0521834910, 9780521834919
DOIs
StatePublished - Jan 1 2007
Externally publishedYes

Fingerprint

Substance-Related Disorders
Norepinephrine
Opiate Alkaloids
Pharmaceutical Preparations
Nicotine
Aptitude
Ego
Social Problems
Amphetamine
Therapeutics
Cocaine
Dopamine
Maintenance
Alcohols
Drug Therapy

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Broom, S. L., & Yamamoto, B. (2007). Role of norepinephrine in substance abuse. In Brain Norepinephrine: Neurobiology and Therapeutics (pp. 610-627). Cambridge University Press. https://doi.org/10.1017/CBO9780511544156.022

Role of norepinephrine in substance abuse. / Broom, Susan L.; Yamamoto, Bryan.

Brain Norepinephrine: Neurobiology and Therapeutics. Cambridge University Press, 2007. p. 610-627.

Research output: Chapter in Book/Report/Conference proceedingChapter

Broom, SL & Yamamoto, B 2007, Role of norepinephrine in substance abuse. in Brain Norepinephrine: Neurobiology and Therapeutics. Cambridge University Press, pp. 610-627. https://doi.org/10.1017/CBO9780511544156.022
Broom SL, Yamamoto B. Role of norepinephrine in substance abuse. In Brain Norepinephrine: Neurobiology and Therapeutics. Cambridge University Press. 2007. p. 610-627 https://doi.org/10.1017/CBO9780511544156.022
Broom, Susan L. ; Yamamoto, Bryan. / Role of norepinephrine in substance abuse. Brain Norepinephrine: Neurobiology and Therapeutics. Cambridge University Press, 2007. pp. 610-627
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