Role of oxidative stress in diabetic nephropathy

Nina Vasavada, Rajiv Agarwal

Research output: Contribution to journalArticle

66 Scopus citations


Accumulating research suggests that oxidative stress is a significant contributor to the pathogenesis of diabetic nephropathy. The normal kidney generates a substantial amount of oxidative stress because of its high metabolic activity that is balanced by an extensive antioxidant system. However, in pathologic states such as hyperglycemia, nitroso-oxidant balance shifts toward a pro-oxidant state that accelerates tissue and vascular injury. This oxidative damage progresses concomitant with worsening glucose metabolism, vascular dysfunction, and kidney disease. Accordingly, strategies to reduce oxidative stress in diabetes mellitus may exert favorable effects on the progression of diabetic nephropathy.

Original languageEnglish (US)
Pages (from-to)146-154
Number of pages9
JournalAdvances in Chronic Kidney Disease
Issue number2
StatePublished - Apr 2005


  • Diabetes mellitus
  • Diabetic nephropathies
  • Oxidative stress
  • Proteinuria
  • Reactive oxygen species

ASJC Scopus subject areas

  • Nephrology

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