Role of oxidative stress in diabetic nephropathy

Nina Vasavada, Rajiv Agarwal

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Accumulating research suggests that oxidative stress is a significant contributor to the pathogenesis of diabetic nephropathy. The normal kidney generates a substantial amount of oxidative stress because of its high metabolic activity that is balanced by an extensive antioxidant system. However, in pathologic states such as hyperglycemia, nitroso-oxidant balance shifts toward a pro-oxidant state that accelerates tissue and vascular injury. This oxidative damage progresses concomitant with worsening glucose metabolism, vascular dysfunction, and kidney disease. Accordingly, strategies to reduce oxidative stress in diabetes mellitus may exert favorable effects on the progression of diabetic nephropathy.

Original languageEnglish
Pages (from-to)146-154
Number of pages9
JournalAdvances in Chronic Kidney Disease
Volume12
Issue number2
DOIs
StatePublished - Apr 2005

Fingerprint

Diabetic Nephropathies
Oxidative Stress
Vascular System Injuries
Kidney Diseases
Vascular Diseases
Oxidants
Hyperglycemia
Reactive Oxygen Species
Diabetes Mellitus
Antioxidants
Kidney
Glucose
Research

Keywords

  • Diabetes mellitus
  • Diabetic nephropathies
  • Oxidative stress
  • Proteinuria
  • Reactive oxygen species

ASJC Scopus subject areas

  • Nephrology

Cite this

Role of oxidative stress in diabetic nephropathy. / Vasavada, Nina; Agarwal, Rajiv.

In: Advances in Chronic Kidney Disease, Vol. 12, No. 2, 04.2005, p. 146-154.

Research output: Contribution to journalArticle

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