Role of positive airway pressure on pulmonary acinar perfusion heterogeneity

N. Tanabe, T. M. Todoran, G. M. Zenk, J. Aono, Jr Wagner W.W., Robert Presson

Research output: Contribution to journalArticle

Abstract

Perfusion of the pulmonary acinus has been shown to be generally homogeneous, but there is a significant component that is heterogeneous. To investigate the contribution of the alveolar septal capillary network to acinar perfusion heterogeneity, the passage of fluorescent dye boluses through the subpleural microcirculation of isolated dog lung lobes was videotaped using fluorescence microscopy. As the videotapes were replayed, dye-dilution curves were recorded from each of the tributary branches of Y-shaped venules that drained single acini. For each Y-shaped venule, the mean appearance time difference between the pair of tributary branches was calculated from the dye curves. When the complex septal capillary networks were derecruited by high positive airway pressure, venular perfusion became proportionally more homogeneous. This result shows that septal capillary resistance and pathlength differences are important contributors to intra-acinar perfusion heterogeneity.

Original languageEnglish (US)
Pages (from-to)1943-1948
Number of pages6
JournalJournal of Applied Physiology
Volume89
Issue number5
StatePublished - 2000
Externally publishedYes

Fingerprint

Perfusion
Pressure
Lung
Venules
Coloring Agents
Capillary Resistance
Videotape Recording
Microcirculation
Fluorescent Dyes
Fluorescence Microscopy
Dogs

Keywords

  • Capillary recruitment
  • Corner vessels
  • Dogs
  • Dye dilution
  • Microcirculation
  • Pulmonary capillaries

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Tanabe, N., Todoran, T. M., Zenk, G. M., Aono, J., Wagner W.W., J., & Presson, R. (2000). Role of positive airway pressure on pulmonary acinar perfusion heterogeneity. Journal of Applied Physiology, 89(5), 1943-1948.

Role of positive airway pressure on pulmonary acinar perfusion heterogeneity. / Tanabe, N.; Todoran, T. M.; Zenk, G. M.; Aono, J.; Wagner W.W., Jr; Presson, Robert.

In: Journal of Applied Physiology, Vol. 89, No. 5, 2000, p. 1943-1948.

Research output: Contribution to journalArticle

Tanabe, N, Todoran, TM, Zenk, GM, Aono, J, Wagner W.W., J & Presson, R 2000, 'Role of positive airway pressure on pulmonary acinar perfusion heterogeneity', Journal of Applied Physiology, vol. 89, no. 5, pp. 1943-1948.
Tanabe N, Todoran TM, Zenk GM, Aono J, Wagner W.W. J, Presson R. Role of positive airway pressure on pulmonary acinar perfusion heterogeneity. Journal of Applied Physiology. 2000;89(5):1943-1948.
Tanabe, N. ; Todoran, T. M. ; Zenk, G. M. ; Aono, J. ; Wagner W.W., Jr ; Presson, Robert. / Role of positive airway pressure on pulmonary acinar perfusion heterogeneity. In: Journal of Applied Physiology. 2000 ; Vol. 89, No. 5. pp. 1943-1948.
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