Role of Rho kinases in abnormal and normal hematopoiesis

Raghuveer Singh Mali, Simryn Kapur, Reuben Kapur

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

PURPOSE OF REVIEW: Rho kinases (ROCKs) are involved in regulating a variety of physiologic functions including cytoskeletal reorganization, migration, adhesion, survival and proliferation. They do so via activating several different downstream substrates such as myosin light chain phosphatase, LIM kinase and ezrin/radixin/moesin proteins. To date, most of the conclusions with regard to the function of ROCKs have involved the use of cell line models, pharmacologic inhibitors and dominant negative approaches. Importantly, the role of ROCK in hematopoiesis or leukemogenesis in the context of whole organism remains poorly understood. RECENT FINDINGS: Recent studies utilizing mice deficient in the expression of ROCK1 have begun to shed some light into the physiologic role(s) of ROCK in both normal and abnormal hematopoiesis. Findings, thus far, suggest that ROCK plays an essential role in regulating growth and survival in different hematopoietic lineages via distinct mechanisms, in part, by utilizing distinct downstream substrates including maintaining the activation of tumor-suppressor genes. SUMMARY: In blood cells, emerging data suggest that ROCK plays an essential role in negatively regulating inflammatory and erythropoietic stress and positively regulates the growth and survival of leukemic cells.

Original languageEnglish
Pages (from-to)271-275
Number of pages5
JournalCurrent Opinion in Hematology
Volume21
Issue number4
DOIs
StatePublished - 2014

Fingerprint

rho-Associated Kinases
Hematopoiesis
Lim Kinases
Myosin-Light-Chain Phosphatase
Growth
Tumor Suppressor Genes
Blood Cells
Cell Survival
Cell Line
Proteins
ezrin
moesin
radixin

Keywords

  • Erythropoiesis and hematopoietic stem cells
  • Leukemia
  • Rho kinase

ASJC Scopus subject areas

  • Hematology

Cite this

Role of Rho kinases in abnormal and normal hematopoiesis. / Mali, Raghuveer Singh; Kapur, Simryn; Kapur, Reuben.

In: Current Opinion in Hematology, Vol. 21, No. 4, 2014, p. 271-275.

Research output: Contribution to journalArticle

Mali, Raghuveer Singh ; Kapur, Simryn ; Kapur, Reuben. / Role of Rho kinases in abnormal and normal hematopoiesis. In: Current Opinion in Hematology. 2014 ; Vol. 21, No. 4. pp. 271-275.
@article{64813b5a342747ddbf9a8a93d16f52f0,
title = "Role of Rho kinases in abnormal and normal hematopoiesis",
abstract = "Lippincott Williams &Wilkins.",
keywords = "Erythropoiesis and hematopoietic stem cells, Leukemia, Rho kinase",
author = "Mali, {Raghuveer Singh} and Simryn Kapur and Reuben Kapur",
year = "2014",
doi = "10.1097/MOH.0000000000000056",
language = "English",
volume = "21",
pages = "271--275",
journal = "Current Opinion in Hematology",
issn = "1065-6251",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Role of Rho kinases in abnormal and normal hematopoiesis

AU - Mali, Raghuveer Singh

AU - Kapur, Simryn

AU - Kapur, Reuben

PY - 2014

Y1 - 2014

N2 - Lippincott Williams &Wilkins.

AB - Lippincott Williams &Wilkins.

KW - Erythropoiesis and hematopoietic stem cells

KW - Leukemia

KW - Rho kinase

UR - http://www.scopus.com/inward/record.url?scp=84902240698&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84902240698&partnerID=8YFLogxK

U2 - 10.1097/MOH.0000000000000056

DO - 10.1097/MOH.0000000000000056

M3 - Article

VL - 21

SP - 271

EP - 275

JO - Current Opinion in Hematology

JF - Current Opinion in Hematology

SN - 1065-6251

IS - 4

ER -