PURPOSE OF REVIEW: Rho kinases (ROCKs) are involved in regulating a variety of physiologic functions including cytoskeletal reorganization, migration, adhesion, survival and proliferation. They do so via activating several different downstream substrates such as myosin light chain phosphatase, LIM kinase and ezrin/radixin/moesin proteins. To date, most of the conclusions with regard to the function of ROCKs have involved the use of cell line models, pharmacologic inhibitors and dominant negative approaches. Importantly, the role of ROCK in hematopoiesis or leukemogenesis in the context of whole organism remains poorly understood. RECENT FINDINGS: Recent studies utilizing mice deficient in the expression of ROCK1 have begun to shed some light into the physiologic role(s) of ROCK in both normal and abnormal hematopoiesis. Findings, thus far, suggest that ROCK plays an essential role in regulating growth and survival in different hematopoietic lineages via distinct mechanisms, in part, by utilizing distinct downstream substrates including maintaining the activation of tumor-suppressor genes. SUMMARY: In blood cells, emerging data suggest that ROCK plays an essential role in negatively regulating inflammatory and erythropoietic stress and positively regulates the growth and survival of leukemic cells.
- Erythropoiesis and hematopoietic stem cells
- Rho kinase
ASJC Scopus subject areas
Role of Rho kinases in abnormal and normal hematopoiesis. / Mali, Raghuveer Singh; Kapur, Simryn; Kapur, Reuben.In: Current Opinion in Hematology, Vol. 21, No. 4, 2014, p. 271-275.
Research output: Contribution to journal › Article
TY - JOUR
T1 - Role of Rho kinases in abnormal and normal hematopoiesis
AU - Mali, Raghuveer Singh
AU - Kapur, Simryn
AU - Kapur, Reuben
PY - 2014
Y1 - 2014
N2 - Lippincott Williams &Wilkins.
AB - Lippincott Williams &Wilkins.
KW - Erythropoiesis and hematopoietic stem cells
KW - Leukemia
KW - Rho kinase
UR - http://www.scopus.com/inward/record.url?scp=84902240698&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84902240698&partnerID=8YFLogxK
U2 - 10.1097/MOH.0000000000000056
DO - 10.1097/MOH.0000000000000056
M3 - Article
C2 - 24867289
AN - SCOPUS:84902240698
VL - 21
SP - 271
EP - 275
JO - Current Opinion in Hematology
JF - Current Opinion in Hematology
SN - 1065-6251
IS - 4