Role of STAT3 pathway in genitourinary tumors

Matteo Santoni, Alessandro Conti, Francesco Piva, Francesco Massari, Chiara Ciccarese, Luciano Burattini, Liang Cheng, Antonio Lopez-Beltran, Marina Scarpelli, Daniele Santini, Giampaolo Tortora, Stefano Cascinu, Rodolfo Montironi

Research output: Contribution to journalReview article

20 Scopus citations

Abstract

The STAT3 is often dysregulated in genitourinary tumors. In prostate cancer, STAT3 activation correlates with Gleason score and pathological stage and modulates cancer stem cells and epithelial-mesenchymal transition. In addition, STAT3 promotes the progression from carcinoma in situ to invasive bladder cancer and modulates renal cell carcinoma angiogenesis by increasing the expression of HIF1α and VEGF. STAT3 is also involved in the response to tyrosine kinase inhibitors sunitinib and axitinib, in patients with metastatic renal cell carcinoma, and to second-generation androgen receptor inhibitor enzalutamide in patients with advanced prostate cancer. In this review, we describe the role of STAT3 in genitourinary tumors, thus describing its potential for future therapeutic strategies. Regulation of the protein STAT3 is often dysfunctional in genitourinary tumors, including prostate, bladder and kidney cancer. STAT3 is involved in the generation of these tumors and has an effect in their response to treatments. In this review, we describe its role in genitourinary tumors and discuss its potential for use in future therapies.

Original languageEnglish (US)
Article numberFSO15
JournalFuture Science OA
Volume1
Issue number3
DOIs
StatePublished - Nov 2015

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Keywords

  • drug resistance
  • genitourinary tumors
  • metastasis
  • signal transducer and activator of transcription 3
  • tumor microenvironment

ASJC Scopus subject areas

  • Biotechnology

Cite this

Santoni, M., Conti, A., Piva, F., Massari, F., Ciccarese, C., Burattini, L., Cheng, L., Lopez-Beltran, A., Scarpelli, M., Santini, D., Tortora, G., Cascinu, S., & Montironi, R. (2015). Role of STAT3 pathway in genitourinary tumors. Future Science OA, 1(3), [FSO15]. https://doi.org/10.4155/fso.15.13