Role of Tafazzin in mitochondrial function, development and disease

Michael T. Chin, Simon J. Conway

Research output: Contribution to journalReview article


Tafazzin, an enzyme associated with the rare inherited x-linked disorder Barth Syndrome, is a nuclear encoded mitochondrial transacylase that is highly conserved across multiple species and plays an important role in mitochondrial function. Numerous studies have elucidated the mechanisms by which Tafazzin affects mitochondrial function, but its effects on development and susceptibility to adult disease are incompletely understood. The purpose of this review is to highlight previous functional studies across a variety of model organisms, introduce recent studies that show an important role in development, and also to provide an update on the role of Tafazzin in human disease. The profound effects of Tafazzin on cardiac development and adult cardiac homeostasis will be emphasized. These studies underscore the importance of mitochondrial function in cardiac development and disease, and also introduce the concept of Tafazzin as a potential therapeutic modality.

Original languageEnglish (US)
Article number10
JournalJournal of Developmental Biology
Issue number2
StatePublished - Jun 1 2020


  • Barth syndrome
  • Cardiolipin
  • Heart failure
  • Left ventricular noncompaction
  • Mitochondria
  • Rare x-linked genetic disease
  • Tafazzin

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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