Role of Th17 cells and IL-17 in lung transplant rejection

Rebecca A. Shilling, David S. Wilkes

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

In the past decade, advances in immunology have led to the recognition that T cell differentiation is not simply Th1 or Th2 but involves differentiation to other subsets, such as T regulatory cells, T follicular helper cells, and Th17 cells. Th17 cells, characterized by production of IL-17, IL-22, and IL-21, have been implicated in the pathogenesis of autoimmune diseases, like rheumatoid arthritis and multiple sclerosis, but also play an important role in host defense and mucosal immunity. IL-17, with its pleiotropic effects on stromal cells, as well as hematopoietic cells, has long been recognized as a possible mediator of rejection after lung transplantation. Recent data have implicated IL-17 and Th17 cells in the development of autoimmunity and chronic rejection after lung transplantation in both animal models and humans. In this review, we will discuss the current data on Th17 and the prospects for the future for lung transplantation.

Original languageEnglish (US)
Pages (from-to)129-134
Number of pages6
JournalSeminars in Immunopathology
Volume33
Issue number2
DOIs
StatePublished - Mar 1 2011

Fingerprint

Th17 Cells
Lung Transplantation
Interleukin-17
Graft Rejection
Regulatory T-Lymphocytes
Lung
Mucosal Immunity
Stromal Cells
Helper-Inducer T-Lymphocytes
Allergy and Immunology
Autoimmunity
Autoimmune Diseases
Multiple Sclerosis
Cell Differentiation
Rheumatoid Arthritis
Animal Models
T-Lymphocytes

Keywords

  • Alloimmunity
  • Autoimmunity
  • Bronchiolitis obliterans syndrome
  • IL-17
  • Lung transplantation
  • Obliterative bronchiolitis
  • Rejection
  • T cells

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Role of Th17 cells and IL-17 in lung transplant rejection. / Shilling, Rebecca A.; Wilkes, David S.

In: Seminars in Immunopathology, Vol. 33, No. 2, 01.03.2011, p. 129-134.

Research output: Contribution to journalArticle

Shilling, Rebecca A. ; Wilkes, David S. / Role of Th17 cells and IL-17 in lung transplant rejection. In: Seminars in Immunopathology. 2011 ; Vol. 33, No. 2. pp. 129-134.
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