Role of the actin cytoskeleton in ischemia-induced cell injury and repair

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Abstract

This paper reviews the role of the actin cytoskeleton in the establishment and maintenance of surface membrane structure and function in all epithelial cells. It describes in detail certain interactions between the actin cytoskeleton and the surface membrane. Recent studies show that ischemia and/or ATP depletion will rapidly disrupt the actin cytoskeleton, an important event in ischemia-induced cell injury. Finally, the review examines specific functional and structural interactions between the actin cytoskeleton and the surface membrane.

Original languageEnglish (US)
Pages (from-to)761-767
Number of pages7
JournalPediatric Nephrology
Volume11
Issue number6
DOIs
StatePublished - Dec 1 1997

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Keywords

  • Actin cytoskeleton
  • Epithelial cells
  • Ischemia-induced injury
  • Membrane structure and function

ASJC Scopus subject areas

  • Nephrology
  • Pediatrics, Perinatology, and Child Health

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