Role of the immune system in the maintenance of mouse facial motoneuron viability after nerve injury

Kathryn Jones, Craig J. Serpe, Susanna C. Byram, Cynthia A. DeBoy, Virginia M. Sanders

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

In the field of neuroimmunology, an emerging area of research involves the role that the immune system plays in neural injury and repair. Such immune:neural interactions may involve both neuroprotective and neurodestruction actions. To begin to address the compelling, and clinically relevant, issue of how the immune system impacts neural reparative processes, we combined the well described facial nerve injury paradigm, a simple neural injury model, with various immunodeficient mouse models, in order to delineate the contributing immune cells/factors involved in neural injury and repair. We have discovered a role for the CD4+ T cell in mediating facial motoneuron survival after facial nerve injury in the mouse. In this review, we present an overview of our work to date in this field and discuss future directions relevant to understanding key elements in the crosstalk between the immune:neural systems that develops subsequent to injury and/or trauma.

Original languageEnglish (US)
Pages (from-to)12-19
Number of pages8
JournalBrain, Behavior, and Immunity
Volume19
Issue number1
DOIs
StatePublished - Jan 2005
Externally publishedYes

Fingerprint

Motor Neurons
Immune System
Maintenance
Facial Nerve Injuries
Wounds and Injuries
Immunologic Factors
T-Lymphocytes
Research

Keywords

  • CD4 T cell
  • Facial motoneuron
  • Facial nerve injury
  • Immunodeficient mouse models
  • Neurotrophic factors

ASJC Scopus subject areas

  • Immunology
  • Behavioral Neuroscience
  • Endocrine and Autonomic Systems

Cite this

Role of the immune system in the maintenance of mouse facial motoneuron viability after nerve injury. / Jones, Kathryn; Serpe, Craig J.; Byram, Susanna C.; DeBoy, Cynthia A.; Sanders, Virginia M.

In: Brain, Behavior, and Immunity, Vol. 19, No. 1, 01.2005, p. 12-19.

Research output: Contribution to journalArticle

Jones, Kathryn ; Serpe, Craig J. ; Byram, Susanna C. ; DeBoy, Cynthia A. ; Sanders, Virginia M. / Role of the immune system in the maintenance of mouse facial motoneuron viability after nerve injury. In: Brain, Behavior, and Immunity. 2005 ; Vol. 19, No. 1. pp. 12-19.
@article{a601f4c9743a48a387d1e445df74795f,
title = "Role of the immune system in the maintenance of mouse facial motoneuron viability after nerve injury",
abstract = "In the field of neuroimmunology, an emerging area of research involves the role that the immune system plays in neural injury and repair. Such immune:neural interactions may involve both neuroprotective and neurodestruction actions. To begin to address the compelling, and clinically relevant, issue of how the immune system impacts neural reparative processes, we combined the well described facial nerve injury paradigm, a simple neural injury model, with various immunodeficient mouse models, in order to delineate the contributing immune cells/factors involved in neural injury and repair. We have discovered a role for the CD4+ T cell in mediating facial motoneuron survival after facial nerve injury in the mouse. In this review, we present an overview of our work to date in this field and discuss future directions relevant to understanding key elements in the crosstalk between the immune:neural systems that develops subsequent to injury and/or trauma.",
keywords = "CD4 T cell, Facial motoneuron, Facial nerve injury, Immunodeficient mouse models, Neurotrophic factors",
author = "Kathryn Jones and Serpe, {Craig J.} and Byram, {Susanna C.} and DeBoy, {Cynthia A.} and Sanders, {Virginia M.}",
year = "2005",
month = "1",
doi = "10.1016/j.bbi.2004.05.004",
language = "English (US)",
volume = "19",
pages = "12--19",
journal = "Brain, Behavior, and Immunity",
issn = "0889-1591",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - Role of the immune system in the maintenance of mouse facial motoneuron viability after nerve injury

AU - Jones, Kathryn

AU - Serpe, Craig J.

AU - Byram, Susanna C.

AU - DeBoy, Cynthia A.

AU - Sanders, Virginia M.

PY - 2005/1

Y1 - 2005/1

N2 - In the field of neuroimmunology, an emerging area of research involves the role that the immune system plays in neural injury and repair. Such immune:neural interactions may involve both neuroprotective and neurodestruction actions. To begin to address the compelling, and clinically relevant, issue of how the immune system impacts neural reparative processes, we combined the well described facial nerve injury paradigm, a simple neural injury model, with various immunodeficient mouse models, in order to delineate the contributing immune cells/factors involved in neural injury and repair. We have discovered a role for the CD4+ T cell in mediating facial motoneuron survival after facial nerve injury in the mouse. In this review, we present an overview of our work to date in this field and discuss future directions relevant to understanding key elements in the crosstalk between the immune:neural systems that develops subsequent to injury and/or trauma.

AB - In the field of neuroimmunology, an emerging area of research involves the role that the immune system plays in neural injury and repair. Such immune:neural interactions may involve both neuroprotective and neurodestruction actions. To begin to address the compelling, and clinically relevant, issue of how the immune system impacts neural reparative processes, we combined the well described facial nerve injury paradigm, a simple neural injury model, with various immunodeficient mouse models, in order to delineate the contributing immune cells/factors involved in neural injury and repair. We have discovered a role for the CD4+ T cell in mediating facial motoneuron survival after facial nerve injury in the mouse. In this review, we present an overview of our work to date in this field and discuss future directions relevant to understanding key elements in the crosstalk between the immune:neural systems that develops subsequent to injury and/or trauma.

KW - CD4 T cell

KW - Facial motoneuron

KW - Facial nerve injury

KW - Immunodeficient mouse models

KW - Neurotrophic factors

UR - http://www.scopus.com/inward/record.url?scp=9944237897&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=9944237897&partnerID=8YFLogxK

U2 - 10.1016/j.bbi.2004.05.004

DO - 10.1016/j.bbi.2004.05.004

M3 - Article

C2 - 15581733

AN - SCOPUS:9944237897

VL - 19

SP - 12

EP - 19

JO - Brain, Behavior, and Immunity

JF - Brain, Behavior, and Immunity

SN - 0889-1591

IS - 1

ER -