Role of transforming growth factor-β1 in regulation of hematopoiesis

F. W. Ruscetti, S. E. Jacobsen, M. Birchenall-Roberts, Hal Broxmeyer, G. L. Engelmann, C. Dubois, J. R. Keller

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

The data presented above suggest that one possible clinical use of TGF-β would be to protect the bone marrow from the effects of myelosuppressive chemotherapeutic drugs by preventing entry or removing primitive stem cells from the cell cycle. It may also have the additional benefit of reducing the drug-induced neutrophil nadir by stimulating granulopoiesis. The availability of large quantities of recombinant TGF-β will allow study of the pharmacokinetics with different routes of administration, dosage effects, and details of the pleiotropic effects on other cell systems. Experiments are in progress to determine whether TGF-β will allow the delivery of higher amounts or more frequent doses of chemotherapeutic drugs and thus allow increased antitumor efficacy in tumor-bearing animals.

Original languageEnglish (US)
Pages (from-to)31-43
Number of pages13
JournalAnnals of the New York Academy of Sciences
Volume628
StatePublished - 1991

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Hematopoiesis
Transforming Growth Factors
Bearings (structural)
Pharmaceutical Preparations
Pharmacokinetics
Stem cells
Tumors
Cell Cycle
Bone
Animals
Neutrophils
Stem Cells
Bone Marrow
Cells
Availability
Drugs
Neoplasms
Experiments

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Ruscetti, F. W., Jacobsen, S. E., Birchenall-Roberts, M., Broxmeyer, H., Engelmann, G. L., Dubois, C., & Keller, J. R. (1991). Role of transforming growth factor-β1 in regulation of hematopoiesis. Annals of the New York Academy of Sciences, 628, 31-43.

Role of transforming growth factor-β1 in regulation of hematopoiesis. / Ruscetti, F. W.; Jacobsen, S. E.; Birchenall-Roberts, M.; Broxmeyer, Hal; Engelmann, G. L.; Dubois, C.; Keller, J. R.

In: Annals of the New York Academy of Sciences, Vol. 628, 1991, p. 31-43.

Research output: Contribution to journalArticle

Ruscetti, FW, Jacobsen, SE, Birchenall-Roberts, M, Broxmeyer, H, Engelmann, GL, Dubois, C & Keller, JR 1991, 'Role of transforming growth factor-β1 in regulation of hematopoiesis', Annals of the New York Academy of Sciences, vol. 628, pp. 31-43.
Ruscetti FW, Jacobsen SE, Birchenall-Roberts M, Broxmeyer H, Engelmann GL, Dubois C et al. Role of transforming growth factor-β1 in regulation of hematopoiesis. Annals of the New York Academy of Sciences. 1991;628:31-43.
Ruscetti, F. W. ; Jacobsen, S. E. ; Birchenall-Roberts, M. ; Broxmeyer, Hal ; Engelmann, G. L. ; Dubois, C. ; Keller, J. R. / Role of transforming growth factor-β1 in regulation of hematopoiesis. In: Annals of the New York Academy of Sciences. 1991 ; Vol. 628. pp. 31-43.
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