Role of transforming growth factor-beta in bone remodeling

Lynda Bonewald, G. R. Mundy

Research output: Contribution to journalReview article

324 Citations (Scopus)

Abstract

Transforming growth factor-beta (TGF-β) plays a critical role in bone remodeling. TGF-β stimulates matrix protein synthesis, has dramatic effects on the bone cells responsible for bone formation and resorption, and is abundant in bone and bone-conditioned media. Multiple sources of TGF-β have been described. It was initially purified from platelets. Two distinct forms of TGF-β have been purified from bone. The second form, TGF-βII, was initially purified from bone but was then identified in platelets and also as the major TGF-β in the monkey kidney BSC-1 cell line. The two bone-derived factors were called cartilage-inducing Factor A (CIF-A) and cartilage-inducing Factor B (CIF-B), based on their capacity to induce the formation of extracellular matrix proteins, which are characteristic of cartilage. CIF-A is identical to the TGF-β purified from platelets, which is called TGF-βI. CIF-B is the same as TGF-βII, which was sequenced soon after CIF-B was discovered and characterized. There is 70% sequence homology between the two forms. The largest source of TGF-β in the body is present in bone (200 μg/kg tissue), although the most concentrated source is in platelets. TGF-β has multiple effects on bone cells depending on their phenotype and/or stage of differentiation. Osteoblasts, the cells responsible for formation of new bone and perhaps cellular control of bone remodeling, are directly affected by TGF-β, which can induce differentiation or proliferation, depending on the osteoblastic cell type examined. TGF-β inhibits the formation of osteoclast precursors and bone resorption and, in greater concentrations, has inhibitory effects on isolated osteoclasts, the cells responsible for bone resorption. TGF-β may act as a bone-coupling factor linking bone resorption to bone formation.

Original languageEnglish (US)
Pages (from-to)261-276
Number of pages16
JournalClinical Orthopaedics and Related Research
Issue number250
StatePublished - 1990
Externally publishedYes

Fingerprint

Bone Remodeling
Transforming Growth Factor beta
Bone and Bones
Transforming Growth Factor beta2
Blood Platelets
Bone Resorption
Osteogenesis
Cartilage
Osteoclasts
Transforming Growth Factor beta1
Extracellular Matrix Proteins
Conditioned Culture Medium
Sequence Homology
Osteoblasts
Haplorhini

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Surgery

Cite this

Role of transforming growth factor-beta in bone remodeling. / Bonewald, Lynda; Mundy, G. R.

In: Clinical Orthopaedics and Related Research, No. 250, 1990, p. 261-276.

Research output: Contribution to journalReview article

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