Rôle de l'enzyme de conversion TNF (TACE/ADAM17) et des protéines associées dans la maladie coronaire et les événements cardiaques

Translated title of the contribution: Role of tumour necrosis factor alpha converting enzyme (TACE/ADAM17) and associated proteins in coronary artery disease and cardiac events

Melody Chemaly, Victoria McGilligan, Mark Gibson, Matthias Clauss, Steven Watterson, H. Denis Alexander, Anthony John Bjourson, Aaron Peace

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

Tumour necrosis factor alpha converting enzyme (TACE/ADAM17) is a member of the A disintegrin and metalloproteinase (ADAM) family of ectodomain shedding proteinases. It regulates many inflammatory processes by cleaving several transmembrane proteins, including tumour necrosis factor alpha (TNFα) and its receptors tumour necrosis factor alpha receptor 1 and tumour necrosis factor alpha receptor 2. There is evidence that TACE is involved in several inflammatory diseases, such as ischaemia, heart failure, arthritis, atherosclerosis, diabetes and cancer as well as neurological and immune diseases. This review summarizes the latest discoveries regarding the mechanism of action and regulation of TACE. It also focuses on the role of TACE in atherosclerosis and coronary artery disease (CAD), highlighting clinical studies that have investigated its expression and protein activity. The multitude of substrates cleaved by TACE make this enzyme an attractive target for therapy and a candidate for biomarker research and development in CAD.

Translated title of the contributionRole of tumour necrosis factor alpha converting enzyme (TACE/ADAM17) and associated proteins in coronary artery disease and cardiac events
Original languageFrench
Pages (from-to)700-711
Number of pages12
JournalArchives of Cardiovascular Diseases
Volume110
Issue number12
DOIs
StatePublished - Dec 2017

Keywords

  • Atherosclerosis
  • Biomarker
  • TACE
  • TNFα
  • Transmembrane proteins

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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