Roles of the LHX3 and LHX4 LIM-homeodomain factors in pituitary development

Rachel D. Mullen, Stephanie C. Colvin, Chad S. Hunter, Jesse J. Savage, Emily C. Walvoord, Amrit P.S. Bhangoo, Svetlana Ten, Johannes Weigel, Roland W. Pfäffle, Simon J. Rhodes

Research output: Contribution to journalReview article

58 Scopus citations

Abstract

The LHX3 and LHX4 LIM-homeodomain transcription factors play essential roles in pituitary gland and nervous system development. Mutations in the genes encoding these regulatory proteins are associated with combined hormone deficiency diseases in humans and animal models. Patients with these diseases have complex syndromes involving short stature, and reproductive and metabolic disorders. Analyses of the features of these diseases and the biochemical properties of the LHX3 and LHX4 proteins will facilitate a better understanding of the molecular pathways that regulate the development of the specialized hormone-secreting cells of the mammalian anterior pituitary gland.

Original languageEnglish (US)
Pages (from-to)190-195
Number of pages6
JournalMolecular and Cellular Endocrinology
Volume265-266
Issue numberSUPPL.
DOIs
StatePublished - Feb 1 2007

Keywords

  • Anterior pituitary
  • Growth
  • Hormone
  • Transcription

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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    Mullen, R. D., Colvin, S. C., Hunter, C. S., Savage, J. J., Walvoord, E. C., Bhangoo, A. P. S., Ten, S., Weigel, J., Pfäffle, R. W., & Rhodes, S. J. (2007). Roles of the LHX3 and LHX4 LIM-homeodomain factors in pituitary development. Molecular and Cellular Endocrinology, 265-266(SUPPL.), 190-195. https://doi.org/10.1016/j.mce.2006.12.019