Roles of the LHX3 and LHX4 LIM-homeodomain factors in pituitary development

Rachel D. Mullen, Stephanie C. Colvin, Chad S. Hunter, Jesse J. Savage, Emily Walvoord, Amrit P S Bhangoo, Svetlana Ten, Johannes Weigel, Roland W. Pfäffle, Simon Rhodes

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

The LHX3 and LHX4 LIM-homeodomain transcription factors play essential roles in pituitary gland and nervous system development. Mutations in the genes encoding these regulatory proteins are associated with combined hormone deficiency diseases in humans and animal models. Patients with these diseases have complex syndromes involving short stature, and reproductive and metabolic disorders. Analyses of the features of these diseases and the biochemical properties of the LHX3 and LHX4 proteins will facilitate a better understanding of the molecular pathways that regulate the development of the specialized hormone-secreting cells of the mammalian anterior pituitary gland.

Original languageEnglish
Pages (from-to)190-195
Number of pages6
JournalMolecular and Cellular Endocrinology
Volume265-266
Issue numberSUPPL.
DOIs
StatePublished - Feb 2007

Fingerprint

Hormones
Deficiency Diseases
Anterior Pituitary Gland
Pituitary Gland
Regulator Genes
Nervous System
Proteins
Gene encoding
Transcription Factors
Animal Models
Neurology
Mutation
Animals
SHORT syndrome

Keywords

  • Anterior pituitary
  • Growth
  • Hormone
  • Transcription

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Roles of the LHX3 and LHX4 LIM-homeodomain factors in pituitary development. / Mullen, Rachel D.; Colvin, Stephanie C.; Hunter, Chad S.; Savage, Jesse J.; Walvoord, Emily; Bhangoo, Amrit P S; Ten, Svetlana; Weigel, Johannes; Pfäffle, Roland W.; Rhodes, Simon.

In: Molecular and Cellular Endocrinology, Vol. 265-266, No. SUPPL., 02.2007, p. 190-195.

Research output: Contribution to journalArticle

Mullen, RD, Colvin, SC, Hunter, CS, Savage, JJ, Walvoord, E, Bhangoo, APS, Ten, S, Weigel, J, Pfäffle, RW & Rhodes, S 2007, 'Roles of the LHX3 and LHX4 LIM-homeodomain factors in pituitary development', Molecular and Cellular Endocrinology, vol. 265-266, no. SUPPL., pp. 190-195. https://doi.org/10.1016/j.mce.2006.12.019
Mullen, Rachel D. ; Colvin, Stephanie C. ; Hunter, Chad S. ; Savage, Jesse J. ; Walvoord, Emily ; Bhangoo, Amrit P S ; Ten, Svetlana ; Weigel, Johannes ; Pfäffle, Roland W. ; Rhodes, Simon. / Roles of the LHX3 and LHX4 LIM-homeodomain factors in pituitary development. In: Molecular and Cellular Endocrinology. 2007 ; Vol. 265-266, No. SUPPL. pp. 190-195.
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