Roles of the SHP-1 tyrosine phosphatase in the negative regulation of cell signalling

Jinyi Zhang, Ally Khan Somani, Katherine A. Siminovitch

Research output: Contribution to journalArticle

268 Scopus citations

Abstract

The critical role for the SH2 domain-containing SHP-1 tyrosine phosphatase in regulating haemopoietic cell behaviour was initially revealed by data linking SHP-1 deficiency to the systemic autoimmunity and severe inflammation exhibited by motheaten mice. This discovery laid the groundwork for the identification of SHP-1 as an inhibitor of activation-promoting signalling cascades and for the coincident demonstration that protein tyrosine phosphatases (PTPs) such as SHP-1 show considerable specificity with respect to the mechanisms whereby they modulate the biochemical and biological sequelae of extracellular simulation. As outlined in this review, SHP-1 has now been implicated in the regulation of a myriad of signalling cascades and cell functions. As a result, the cumulative data generated from studies of this PTP have elucidated not only the functional relevance of SHP-1, but also a number of novel paradigms as to the molecular mechanisms whereby signalling cascades are regulated so as to either augment or abrogate specific cell behaviours. (C) 2000 Academic Press.

Original languageEnglish (US)
Pages (from-to)361-378
Number of pages18
JournalSeminars in Immunology
Volume12
Issue number4
DOIs
StatePublished - Jan 1 2000
Externally publishedYes

Keywords

  • Lymphocytes
  • Protein-tyrosine phosphatases
  • SHP-1
  • Signal transduction

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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