Rotating single-shot acquisition (RoSA) with composite reconstruction for fast high-resolution diffusion imaging

Qiuting Wen, Chandana Kodiweera, Brian M. Dale, Giri Shivraman, Yu-Chien Wu

Research output: Contribution to journalArticle

2 Scopus citations


Purpose: To accelerate high-resolution diffusion imaging, rotating single-shot acquisition (RoSA) with composite reconstruction is proposed. Acceleration was achieved by acquiring only one rotating single-shot blade per diffusion direction, and high-resolution diffusion-weighted (DW) images were reconstructed by using similarities of neighboring DW images. A parallel imaging technique was implemented in RoSA to further improve the image quality and acquisition speed. RoSA performance was evaluated by simulation and human experiments. Methods: A brain tensor phantom was developed to determine an optimal blade size and rotation angle by considering similarity in DW images, off-resonance effects, and k-space coverage. With the optimal parameters, RoSA MR pulse sequence and reconstruction algorithm were developed to acquire human brain data. For comparison, multishot echo planar imaging (EPI) and conventional single-shot EPI sequences were performed with matched scan time, resolution, field of view, and diffusion directions. Results: The simulation indicated an optimal blade size of 48 × 256 and a 30 ° rotation angle. For 1 × 1 mm2 in-plane resolution, RoSA was 12 times faster than the multishot acquisition with comparable image quality. With the same acquisition time as SS-EPI, RoSA provided superior image quality and minimum geometric distortion. Conclusion: RoSA offers fast, high-quality, high-resolution diffusion images. The composite image reconstruction is model-free and compatible with various diffusion computation approaches including parametric and nonparametric analyses. Magn Reson Med 79:264–275, 2018.

Original languageEnglish (US)
Pages (from-to)264-275
Number of pages12
JournalMagnetic Resonance in Medicine
Issue number1
StatePublished - Jan 1 2018


  • blade
  • diffusion imaging
  • dMRI
  • fast
  • high resolution
  • single shot

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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