RPE lipofuscin and its role in retinal pathobiology

Janet R. Sparrow, Mike Boulton

Research output: Contribution to journalReview article

426 Scopus citations


Emerging evidence indicates that the autofluorescent pigments that accumulate as lipofuscin in retinal pigment epithelial (RPE) cells may reach levels that contribute to a decline in cell function. Since recent findings with respect to the origin, composition and adverse effects of RPE lipofuscin have informed our view of this material, the goal of this article is to review our current understanding of these issues.

Original languageEnglish (US)
Pages (from-to)595-606
Number of pages12
JournalExperimental eye research
Issue number5
StatePublished - May 2005



  • A2E
  • Age-related macular degeneration
  • Light damage
  • Lipofuscin
  • Photooxidation
  • Retinal pigment epithelial cell

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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