Rrp2, a σ 54-dependent transcriptional activator of Borrelia burgdorferi, activates rpoS in an enhancer-independent manner

Jon S. Blevins, Haijun Xu, Ming He, Michael V. Norgard, Larry Reitzer, X. Frank Yang

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

Rrp2 is the sole σ 54-dependent transcriptional activator present in the Borrelia burgdorferi genome. We showed that recombinant Rrp2 binds to DNA in a sequence-nonspecific manner. During infection, Rrp2 activates σ 54-dependent rpoS expression without an apparent upstream enhancer element commonly associated with other σ 54-dependent transcriptional activators.

Original languageEnglish (US)
Pages (from-to)2902-2905
Number of pages4
JournalJournal of bacteriology
Volume191
Issue number8
DOIs
StatePublished - Apr 2009

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

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