SAA SUPPRESSION OF IN VITRO ANTIBODY RESPONSE

Merrill D. Benson, Marlene A. Aldo‐Benson

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

In previous studies it has been shown that SAA isolated from serum of casein treated mice can suppress the in vitro antibody response of spleen cells to the T-dependent antigen sheep red blood cells [SRBC]. suppression of antibody response by SAA occurs in the early antigen recognition phase and not in the proliferative phase of the immune response. No effect upon the response of spleen cells to the T-independent antigen DNP-Ficoll was observed suggesting that SAA does not act directly on B-cells. Further studies were done to define the cellular mechanisms by which SAA exerts its effect on antibody response. These data suggest that SAA does not activate suppressor T-cells or cause induction of suppressor T-cells, but instead that SAA affects the interaction of macrophage and T-cells. In addition to these data from the murine system SAA has been shown to affect the response of human peripheral blood lymphocytes to SRBC.

Original languageEnglish (US)
Pages (from-to)121-125
Number of pages5
JournalAnnals of the New York Academy of Sciences
Volume389
Issue number1
DOIs
StatePublished - Jun 1982

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Fingerprint Dive into the research topics of 'SAA SUPPRESSION OF IN VITRO ANTIBODY RESPONSE'. Together they form a unique fingerprint.

  • Cite this