Safety and acceptability of the research lumbar puncture

Elaine R. Peskind, Robert Riekse, Joseph F. Quinn, Jeffrey Kaye, Christopher M. Clark, Martin Farlow, Charles Decarli, Charles Chabal, Darcy Vavrek, Murray A. Raskind, Douglas Galasko

Research output: Contribution to journalArticle

140 Citations (Scopus)

Abstract

Three hundred forty-two subjects underwent 428 research lumbar punctures for studies of cerebrospinal fluid (CSF) biomarkers. Subjects were 67 Alzheimer disease or mild cognitive impairment (AD/MCI) patients and 275 cognitively normal adults aged 21 to 88. Lumbar puncture was performed in the lateral decubitus or sitting position using the Sprotte 24g atraumatic spinal needle. Up to 34 ml of cerebrospinal fluid were collected. Anxiety and pain experienced during lumbar puncture were rated on a visual analog scale. The frequency of any adverse event (11.7%), clinically significant adverse events (3.97%), and typical post-lumbar puncture headache (PLPHA) (0.93%) was low. Risk of post-lumbar puncture headache was unrelated to age, gender, position during lumbar puncture, ml of cerebrospinal fluid collected, or minutes of recumbent rest following lumbar puncture. The frequency of post-lumbar puncture headache was lower in AD/MCI (P = 0.03) than any other subject group. Anxiety and pain ratings were low. Younger subjects reported more anxiety than old (P = 0.001) and AD/MCI subjects (P = 0.008) and more pain than older normal subjects (P = 0.013). Pain ratings for women were higher than those for men (P = 0.006). Using the Sprotte 24g spinal needle, research lumbar puncture can be performed with a very low rate of clinically significant adverse events and with good acceptability in cognitively impaired persons and cognitively normal adults of all ages.

Original languageEnglish
Pages (from-to)220-225
Number of pages6
JournalAlzheimer Disease and Associated Disorders
Volume19
Issue number4
DOIs
StatePublished - Oct 2005

Fingerprint

Spinal Puncture
Post-Dural Puncture Headache
Safety
Research
Cerebrospinal Fluid
Pain
Alzheimer Disease
Anxiety
Needles
Posture
Visual Analog Scale
Biomarkers
Cognitive Dysfunction

Keywords

  • Alzheimer disease
  • Lumbar puncture
  • Post lumbar-puncture headache

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Neuroscience(all)

Cite this

Peskind, E. R., Riekse, R., Quinn, J. F., Kaye, J., Clark, C. M., Farlow, M., ... Galasko, D. (2005). Safety and acceptability of the research lumbar puncture. Alzheimer Disease and Associated Disorders, 19(4), 220-225. https://doi.org/10.1097/01.wad.0000194014.43575.fd

Safety and acceptability of the research lumbar puncture. / Peskind, Elaine R.; Riekse, Robert; Quinn, Joseph F.; Kaye, Jeffrey; Clark, Christopher M.; Farlow, Martin; Decarli, Charles; Chabal, Charles; Vavrek, Darcy; Raskind, Murray A.; Galasko, Douglas.

In: Alzheimer Disease and Associated Disorders, Vol. 19, No. 4, 10.2005, p. 220-225.

Research output: Contribution to journalArticle

Peskind, ER, Riekse, R, Quinn, JF, Kaye, J, Clark, CM, Farlow, M, Decarli, C, Chabal, C, Vavrek, D, Raskind, MA & Galasko, D 2005, 'Safety and acceptability of the research lumbar puncture', Alzheimer Disease and Associated Disorders, vol. 19, no. 4, pp. 220-225. https://doi.org/10.1097/01.wad.0000194014.43575.fd
Peskind, Elaine R. ; Riekse, Robert ; Quinn, Joseph F. ; Kaye, Jeffrey ; Clark, Christopher M. ; Farlow, Martin ; Decarli, Charles ; Chabal, Charles ; Vavrek, Darcy ; Raskind, Murray A. ; Galasko, Douglas. / Safety and acceptability of the research lumbar puncture. In: Alzheimer Disease and Associated Disorders. 2005 ; Vol. 19, No. 4. pp. 220-225.
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