Safety and efficacy of two reduced dosing regimens of sodium phosphate tablets for preparation prior to colonoscopy

D. K. Rex, R. Chasen, M. B. Pochapin

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

Objectives: To evaluate the safety and efficacy of two reduced dosing regimens of sodium phosphate tablets (Visicol, InKine Pharmaceutical Co. Inc., Blue Bell, PA, USA) for colon cleansing prior to colonoscopy. Methods: In a randomized, multicentre, endoscopist-blinded clinical study, adults undergoing colonoscopy received either 28 tablets (42 g) or 32 tablets (48 g) of sodium phosphate for colon cleansing. The endoscopist used a validated four-point scale to rate the overall quality of colon cleansing as well as cleansing in the ascending colon. Adverse events were collected and evaluated. Results: The quality of overall colon cleansing was 'excellent' or 'good' in 84% or more of both groups, with no significant difference between the two doses. No patient had a preparation rated as 'inadequate' or required a repeat procedure. All patients were able to complete the assigned dose of tablets, and there were no deaths, serious adverse events or dropouts from the study. Conclusions: A reduced tablet regimen for sodium phosphate tablets, using either 28 or 32 tablets, is well tolerated and effective for colon cleansing prior to colonoscopy.

Original languageEnglish (US)
Pages (from-to)937-944
Number of pages8
JournalAlimentary Pharmacology and Therapeutics
Volume16
Issue number5
DOIs
StatePublished - 2002

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology
  • Pharmacology (medical)

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