Safety of discontinuation of maintenance therapy for disseminated histoplasmosis after immunologic response to antiretroviral therapy

Mitchell Goldman, Robert Zackin, Carl J. Fichtenbaum, Daniel J. Skiest, Susan L. Koletar, Richard Hafner, L. Joseph Wheat, Peter M. Nyangweso, Constantin T. Yiannoutsos, Carol T. Schnizlein-Bick, Susan Owens, Judith A. Aberg

Research output: Contribution to journalArticle

103 Scopus citations

Abstract

We performed a prospective observational study to assess the safety of stopping maintenance therapy for disseminated histoplasmosis among human immunodeficiency virus-infected patients after response to antiretroviral therapy. All subjects received at least 12 months of antifungal therapy and 6 months of antiretroviral therapy before entry. Negative results of fungal blood cultures, urine and serum Histoplasma antigen level of <4.1 units, and CD4+ T cell count of >150 cells/mm3 were required for eligibility. Thirty-two subjects were enrolled; the median CD4+ T cell count at study entry was 289 cells/mm3. No relapses of histoplasmosis occurred after a median duration of follow-up of 24 months. This corresponded to an observed relapse rate of 0 cases per 65 person-years. The median CD4+ T cell count at final study visit was 338 cells/mm 3. Discontinuation of antifungal maintenance therapy appears to be safe for patients with acquired immunodeficiency syndrome with previously treated disseminated histoplasmosis and sustained immunologic improvement in response to antiretroviral therapy.

Original languageEnglish (US)
Pages (from-to)1485-1489
Number of pages5
JournalClinical Infectious Diseases
Volume38
Issue number10
DOIs
StatePublished - May 15 2004

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ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Goldman, M., Zackin, R., Fichtenbaum, C. J., Skiest, D. J., Koletar, S. L., Hafner, R., Wheat, L. J., Nyangweso, P. M., Yiannoutsos, C. T., Schnizlein-Bick, C. T., Owens, S., & Aberg, J. A. (2004). Safety of discontinuation of maintenance therapy for disseminated histoplasmosis after immunologic response to antiretroviral therapy. Clinical Infectious Diseases, 38(10), 1485-1489. https://doi.org/10.1086/420749