Salivary androgen-binding protein variation in Mus and other rodents

R. C. Karn, Stephen Dlouhy

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

We have searched for genetic variation in the expression of salivary androgen-binding protein (ABP) in a wide variety of mice and other rodents. ABP was present in the salivas of mice of all species and subspecies studied. Genetic studies have identified three common variants of the ABP Alpha subunit (Abpaa, Abpab, and Abpac) in Mus musculus populations with distributions that correspond roughly to those of the subspecies studied (domesticus, musculus, and castaneus, respectively). It appears that the ABP a and b polymorphisms conform to the hybrid zone between the domesticus and musculus subspecies characterized by others. Our studies suggest that the presence of Abpab in inbred strains may be due to a M. m. musculus contribution, perhaps via oriental fancy mice bred to European mice in the early lines leading to the common inbred strains. The relatively common occurrence of the ABP a type in other Mus species leads us to conclude that it is the ancestral type in mice. Further, the observation of what amounts to unique alleles in the three different subspecies indicates that microvolution of the protein has occurred. In a broader survey, ABP was also found in the salivas of Murid and Cricetid rodents generally. These findings suggest that ABP has an important functional role in rodent salivas.

Original languageEnglish
Pages (from-to)453-458
Number of pages6
JournalJournal of Heredity
Volume82
Issue number6
StatePublished - Nov 1991

Fingerprint

Androgen-Binding Protein
Mus
androgens
binding proteins
Rodentia
rodents
Protein
Mouse
saliva
Saliva
mice
Muridae
Protein Subunits
Genetic Variation
Mus musculus
Carrier Proteins
Androgens
Polymorphism
Alleles
Observation

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Genetics(clinical)
  • Biotechnology
  • Molecular Biology
  • Genetics
  • Agricultural and Biological Sciences(all)

Cite this

Salivary androgen-binding protein variation in Mus and other rodents. / Karn, R. C.; Dlouhy, Stephen.

In: Journal of Heredity, Vol. 82, No. 6, 11.1991, p. 453-458.

Research output: Contribution to journalArticle

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