Salivary immunoglobulin A and serum antibodies to Streptococcus mutans ribosomal preparations in dental caries-free and caries-susceptible human subjects

Richard Gregory, S. J. Filler, S. M. Michalek, J. R. McGhee

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Caries-free subjects or individuals with low caries susceptibility exhibited significantly higher (P <0.001) levels of naturally occurring salivary immunoglobulin A (IgA) and serum IgG, IgA, and IgM antibodies to a Streptococcus mutans ribosomal preparation than subjects with high caries susceptibility. Absorption of saliva and serum samples with S. mutans ribosomal preparations, but not with other S. mutans antigens or with Escherichia coli and Neisseria gonorrhoeae ribosomal preparations, removed the antibody activity. Absorption with Streptococcus sanguis ribosomes and NH4Cl-washed S. mutans ribosomes partially removed the anti-S. mutans ribosome antibody activity. These results provide evidence that naturally occurring salivary and serum antibodies to the S. mutans ribosomal preparation correlate with susceptibility to dental caries.

Original languageEnglish (US)
Pages (from-to)348-351
Number of pages4
JournalInfection and Immunity
Volume51
Issue number1
StatePublished - 1986
Externally publishedYes

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Streptococcus mutans
Dental Caries
Immunoglobulin A
Antibodies
Serum
Ribosomes
Dental Caries Susceptibility
Streptococcus sanguis
Neisseria gonorrhoeae
Saliva
Immunoglobulin M
Immunoglobulin G
Escherichia coli
Antigens

ASJC Scopus subject areas

  • Immunology

Cite this

Salivary immunoglobulin A and serum antibodies to Streptococcus mutans ribosomal preparations in dental caries-free and caries-susceptible human subjects. / Gregory, Richard; Filler, S. J.; Michalek, S. M.; McGhee, J. R.

In: Infection and Immunity, Vol. 51, No. 1, 1986, p. 348-351.

Research output: Contribution to journalArticle

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