Salvage chemotherapy in patients with extragonadal nonseminomatous germ cell tumors: The Indiana University experience

Scott B. Saxman, Craig R. Nichols, Lawrence H. Einhorn

Research output: Contribution to journalArticle

92 Scopus citations

Abstract

Purpose: Patients with relapsed extragonadal germ cell tumors (EGCT) are usually treated in an identical fashion as patients with recurrent testicular cancer. However, little is known about the long-term outcome in these patients and whether they have comparable results to patients with a testicular primary tumor. The purpose of this study was to evaluate the effect of salvage chemotherapy on long-term survival in patients with EGCT. Materials and Methods: We conducted a retrospective review of 73 patients with relapsed extragonadal nonseminomatous germ cell tumors (GCTs) treated at Indiana University between 1976 and 1993. All patients received cisplatin- containing regimens as primary chemotherapy. Results: Only five of 73 patients (7%) were long-term disease-free survivors after salvage chemotherapy. The remaining 68 patients are either dead of disease or toxicity (n = 63), or alive with progressive disease (PD) (n = 5). Twenty- eight patients received high-dose chemotherapy with autologous bone marrow transplant (ABMT) at some point during their disease, and none of these patients are continuously disease-free. Conclusion: Although similar salvage chemotherapy strategies will cure approximately 30% of patients with recurrent testicular cancer, new approaches are needed for EGCT.

Original languageEnglish (US)
Pages (from-to)1390-1393
Number of pages4
JournalJournal of Clinical Oncology
Volume12
Issue number7
DOIs
StatePublished - Jul 1994

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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