Salvage therapy for germ cell tumors

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Testicular cancer has become a model for a curable neoplasm. Approximately 70% of patients with disseminated disease will be cured with first-line chemotherapy regimens like cisplatin/etoposide/bleomycin. The concept of salvage therapy is simply to use active drugs not previously used in combination with cisplatin, the most active single agent. This strategy can be used with curative intent if the patient did not exhibit progressive disease during his initial cisplatin combination chemotherapy. Vinblastine/ifosfamide/cisplatin will cure approximately 25% of patients when used as second-line therapy. The cure rate for extragonadal presentation is extremely low, however. High-dose chemotherapy with carboplatin and etoposide with autologous bone marrow transplantation can cure 15% to 20% of patients whose disease progressed during prior cisplatin combination chemotherapy, or when the regimen is used as third-line or later chemotherapy. We are currently evaluating autologous bone marrow transplantation as initial salvage therapy.

Original languageEnglish
Pages (from-to)47-51
Number of pages5
JournalSeminars in Oncology
Volume21
Issue number4 SUPPL. 7
StatePublished - 1994

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Salvage Therapy
Germ Cell and Embryonal Neoplasms
Cisplatin
Autologous Transplantation
Etoposide
Combination Drug Therapy
Bone Marrow Transplantation
Drug Therapy
Ifosfamide
Vinblastine
Carboplatin
Bleomycin
Testicular Neoplasms
Pharmaceutical Preparations
Neoplasms

ASJC Scopus subject areas

  • Oncology

Cite this

Salvage therapy for germ cell tumors. / Einhorn, Lawrence.

In: Seminars in Oncology, Vol. 21, No. 4 SUPPL. 7, 1994, p. 47-51.

Research output: Contribution to journalArticle

Einhorn, L 1994, 'Salvage therapy for germ cell tumors', Seminars in Oncology, vol. 21, no. 4 SUPPL. 7, pp. 47-51.
Einhorn, Lawrence. / Salvage therapy for germ cell tumors. In: Seminars in Oncology. 1994 ; Vol. 21, No. 4 SUPPL. 7. pp. 47-51.
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