SARC009: Phase 2 study of dasatinib in patients with previously treated, high-grade, advanced sarcoma

Scott M. Schuetze, J. Kyle Wathen, David R. Lucas, Edwin Choy, Brian L. Samuels, Arthur P. Staddon, Kristen N. Ganjoo, Margaret Von Mehren, Warren A. Chow, David M. Loeb, Hussein A. Tawbi, Daniel A. Rushing, Shreyaskumar R. Patel, Dafydd G. Thomas, Rashmi Chugh, Denise K. Reinke, Laurence H. Baker

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

BACKGROUND Dasatinib exhibited activity in preclinical models of sarcoma. The Sarcoma Alliance for Research through Collaboration (SARC) conducted a multicenter, phase 2 trial of dasatinib in patients with advanced sarcoma. METHODS Patients received dasatinib twice daily. The primary objective was to estimate the clinical benefit rate (CBR) (complete response or partial response within 6 months or stable disease duration of ≥6 months) with a target of ≥25%. Patients were enrolled into 1 of 7 different cohorts and assessed by imaging every 8 weeks using Choi criteria tumor response and a Bayesian hierarchical design. For each subtype, enrollment was stopped after a minimum of 9 patients were treated if there was a

Original languageEnglish (US)
Pages (from-to)868-874
Number of pages7
JournalCancer
Volume122
Issue number6
DOIs
StatePublished - Mar 15 2016

Fingerprint

Sarcoma
Dasatinib
Research
Neoplasms

Keywords

  • adaptive
  • Bayesian
  • Choi
  • dasatinib
  • phase 2
  • sarcoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Schuetze, S. M., Wathen, J. K., Lucas, D. R., Choy, E., Samuels, B. L., Staddon, A. P., ... Baker, L. H. (2016). SARC009: Phase 2 study of dasatinib in patients with previously treated, high-grade, advanced sarcoma. Cancer, 122(6), 868-874. https://doi.org/10.1002/cncr.29858

SARC009 : Phase 2 study of dasatinib in patients with previously treated, high-grade, advanced sarcoma. / Schuetze, Scott M.; Wathen, J. Kyle; Lucas, David R.; Choy, Edwin; Samuels, Brian L.; Staddon, Arthur P.; Ganjoo, Kristen N.; Von Mehren, Margaret; Chow, Warren A.; Loeb, David M.; Tawbi, Hussein A.; Rushing, Daniel A.; Patel, Shreyaskumar R.; Thomas, Dafydd G.; Chugh, Rashmi; Reinke, Denise K.; Baker, Laurence H.

In: Cancer, Vol. 122, No. 6, 15.03.2016, p. 868-874.

Research output: Contribution to journalArticle

Schuetze, SM, Wathen, JK, Lucas, DR, Choy, E, Samuels, BL, Staddon, AP, Ganjoo, KN, Von Mehren, M, Chow, WA, Loeb, DM, Tawbi, HA, Rushing, DA, Patel, SR, Thomas, DG, Chugh, R, Reinke, DK & Baker, LH 2016, 'SARC009: Phase 2 study of dasatinib in patients with previously treated, high-grade, advanced sarcoma', Cancer, vol. 122, no. 6, pp. 868-874. https://doi.org/10.1002/cncr.29858
Schuetze SM, Wathen JK, Lucas DR, Choy E, Samuels BL, Staddon AP et al. SARC009: Phase 2 study of dasatinib in patients with previously treated, high-grade, advanced sarcoma. Cancer. 2016 Mar 15;122(6):868-874. https://doi.org/10.1002/cncr.29858
Schuetze, Scott M. ; Wathen, J. Kyle ; Lucas, David R. ; Choy, Edwin ; Samuels, Brian L. ; Staddon, Arthur P. ; Ganjoo, Kristen N. ; Von Mehren, Margaret ; Chow, Warren A. ; Loeb, David M. ; Tawbi, Hussein A. ; Rushing, Daniel A. ; Patel, Shreyaskumar R. ; Thomas, Dafydd G. ; Chugh, Rashmi ; Reinke, Denise K. ; Baker, Laurence H. / SARC009 : Phase 2 study of dasatinib in patients with previously treated, high-grade, advanced sarcoma. In: Cancer. 2016 ; Vol. 122, No. 6. pp. 868-874.
@article{9b68692352f2448fa72292e418c4f93c,
title = "SARC009: Phase 2 study of dasatinib in patients with previously treated, high-grade, advanced sarcoma",
abstract = "BACKGROUND Dasatinib exhibited activity in preclinical models of sarcoma. The Sarcoma Alliance for Research through Collaboration (SARC) conducted a multicenter, phase 2 trial of dasatinib in patients with advanced sarcoma. METHODS Patients received dasatinib twice daily. The primary objective was to estimate the clinical benefit rate (CBR) (complete response or partial response within 6 months or stable disease duration of ≥6 months) with a target of ≥25{\%}. Patients were enrolled into 1 of 7 different cohorts and assessed by imaging every 8 weeks using Choi criteria tumor response and a Bayesian hierarchical design. For each subtype, enrollment was stopped after a minimum of 9 patients were treated if there was a",
keywords = "adaptive, Bayesian, Choi, dasatinib, phase 2, sarcoma",
author = "Schuetze, {Scott M.} and Wathen, {J. Kyle} and Lucas, {David R.} and Edwin Choy and Samuels, {Brian L.} and Staddon, {Arthur P.} and Ganjoo, {Kristen N.} and {Von Mehren}, Margaret and Chow, {Warren A.} and Loeb, {David M.} and Tawbi, {Hussein A.} and Rushing, {Daniel A.} and Patel, {Shreyaskumar R.} and Thomas, {Dafydd G.} and Rashmi Chugh and Reinke, {Denise K.} and Baker, {Laurence H.}",
year = "2016",
month = "3",
day = "15",
doi = "10.1002/cncr.29858",
language = "English (US)",
volume = "122",
pages = "868--874",
journal = "Cancer",
issn = "0008-543X",
publisher = "John Wiley and Sons Inc.",
number = "6",

}

TY - JOUR

T1 - SARC009

T2 - Phase 2 study of dasatinib in patients with previously treated, high-grade, advanced sarcoma

AU - Schuetze, Scott M.

AU - Wathen, J. Kyle

AU - Lucas, David R.

AU - Choy, Edwin

AU - Samuels, Brian L.

AU - Staddon, Arthur P.

AU - Ganjoo, Kristen N.

AU - Von Mehren, Margaret

AU - Chow, Warren A.

AU - Loeb, David M.

AU - Tawbi, Hussein A.

AU - Rushing, Daniel A.

AU - Patel, Shreyaskumar R.

AU - Thomas, Dafydd G.

AU - Chugh, Rashmi

AU - Reinke, Denise K.

AU - Baker, Laurence H.

PY - 2016/3/15

Y1 - 2016/3/15

N2 - BACKGROUND Dasatinib exhibited activity in preclinical models of sarcoma. The Sarcoma Alliance for Research through Collaboration (SARC) conducted a multicenter, phase 2 trial of dasatinib in patients with advanced sarcoma. METHODS Patients received dasatinib twice daily. The primary objective was to estimate the clinical benefit rate (CBR) (complete response or partial response within 6 months or stable disease duration of ≥6 months) with a target of ≥25%. Patients were enrolled into 1 of 7 different cohorts and assessed by imaging every 8 weeks using Choi criteria tumor response and a Bayesian hierarchical design. For each subtype, enrollment was stopped after a minimum of 9 patients were treated if there was a

AB - BACKGROUND Dasatinib exhibited activity in preclinical models of sarcoma. The Sarcoma Alliance for Research through Collaboration (SARC) conducted a multicenter, phase 2 trial of dasatinib in patients with advanced sarcoma. METHODS Patients received dasatinib twice daily. The primary objective was to estimate the clinical benefit rate (CBR) (complete response or partial response within 6 months or stable disease duration of ≥6 months) with a target of ≥25%. Patients were enrolled into 1 of 7 different cohorts and assessed by imaging every 8 weeks using Choi criteria tumor response and a Bayesian hierarchical design. For each subtype, enrollment was stopped after a minimum of 9 patients were treated if there was a

KW - adaptive

KW - Bayesian

KW - Choi

KW - dasatinib

KW - phase 2

KW - sarcoma

UR - http://www.scopus.com/inward/record.url?scp=84960410673&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84960410673&partnerID=8YFLogxK

U2 - 10.1002/cncr.29858

DO - 10.1002/cncr.29858

M3 - Article

C2 - 26710211

AN - SCOPUS:84960410673

VL - 122

SP - 868

EP - 874

JO - Cancer

JF - Cancer

SN - 0008-543X

IS - 6

ER -