Sarcoid-Reaction Mimicking Metastatic Malignant Hepatopancreatobiliary Tumors: Report of Two Cases and Review of the Literature

Zhi Ven Fong, Joshua Wong, Warren R. Maley, Nora Sandorfi, Jordan M. Winter, Leonidas Koniaris, Patricia K. Sauter, Charles J. Yeo, Harish Lavu

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Introduction: Sarcoidosis is a multisystem chronic granulomatous disease found predominantly in the lungs and lymph nodes. Its pathologic hallmark is the presence of systemic non-caseating granulomas; however, a variation of this disease known as "sarcoid-like reaction" has been described in patients with underlying cancer. Report: Sarcoid-like reactions in patients with hepatopancreatobiliary (HPB) tumors are rare findings, with only 15 cases having been reported in the English language literature. These reactions can be found in local lymph nodes or in distant organs, and when present in patients with cancer, they can mimic metastatic disease on imaging, potentially resulting in incorrect cancer staging and management. Discussion: We describe two cases of patients with HPB tumors who had distant organ disease on cross-sectional imaging suspicious for metastases, which on further workup were found to be sarcoid-like reactions. We also discuss malignancy-induced sarcoid-like reactions and provide a review of the literature of sarcoid-like reactions in the setting of HPB tumors.

Original languageEnglish (US)
Pages (from-to)1245-1250
Number of pages6
JournalJournal of Gastrointestinal Surgery
Volume16
Issue number6
DOIs
StatePublished - Jun 2012
Externally publishedYes

Fingerprint

Neoplasms
Lymph Nodes
Chronic Granulomatous Disease
Neoplasm Staging
Sarcoidosis
Granuloma
Language
Neoplasm Metastasis
Lung

ASJC Scopus subject areas

  • Surgery
  • Gastroenterology

Cite this

Sarcoid-Reaction Mimicking Metastatic Malignant Hepatopancreatobiliary Tumors : Report of Two Cases and Review of the Literature. / Fong, Zhi Ven; Wong, Joshua; Maley, Warren R.; Sandorfi, Nora; Winter, Jordan M.; Koniaris, Leonidas; Sauter, Patricia K.; Yeo, Charles J.; Lavu, Harish.

In: Journal of Gastrointestinal Surgery, Vol. 16, No. 6, 06.2012, p. 1245-1250.

Research output: Contribution to journalArticle

Fong, Zhi Ven ; Wong, Joshua ; Maley, Warren R. ; Sandorfi, Nora ; Winter, Jordan M. ; Koniaris, Leonidas ; Sauter, Patricia K. ; Yeo, Charles J. ; Lavu, Harish. / Sarcoid-Reaction Mimicking Metastatic Malignant Hepatopancreatobiliary Tumors : Report of Two Cases and Review of the Literature. In: Journal of Gastrointestinal Surgery. 2012 ; Vol. 16, No. 6. pp. 1245-1250.
@article{9fbfddfcf62748609f012ad027f89b06,
title = "Sarcoid-Reaction Mimicking Metastatic Malignant Hepatopancreatobiliary Tumors: Report of Two Cases and Review of the Literature",
abstract = "Introduction: Sarcoidosis is a multisystem chronic granulomatous disease found predominantly in the lungs and lymph nodes. Its pathologic hallmark is the presence of systemic non-caseating granulomas; however, a variation of this disease known as {"}sarcoid-like reaction{"} has been described in patients with underlying cancer. Report: Sarcoid-like reactions in patients with hepatopancreatobiliary (HPB) tumors are rare findings, with only 15 cases having been reported in the English language literature. These reactions can be found in local lymph nodes or in distant organs, and when present in patients with cancer, they can mimic metastatic disease on imaging, potentially resulting in incorrect cancer staging and management. Discussion: We describe two cases of patients with HPB tumors who had distant organ disease on cross-sectional imaging suspicious for metastases, which on further workup were found to be sarcoid-like reactions. We also discuss malignancy-induced sarcoid-like reactions and provide a review of the literature of sarcoid-like reactions in the setting of HPB tumors.",
author = "Fong, {Zhi Ven} and Joshua Wong and Maley, {Warren R.} and Nora Sandorfi and Winter, {Jordan M.} and Leonidas Koniaris and Sauter, {Patricia K.} and Yeo, {Charles J.} and Harish Lavu",
year = "2012",
month = "6",
doi = "10.1007/s11605-011-1820-3",
language = "English (US)",
volume = "16",
pages = "1245--1250",
journal = "Journal of Gastrointestinal Surgery",
issn = "1091-255X",
publisher = "Springer New York",
number = "6",

}

TY - JOUR

T1 - Sarcoid-Reaction Mimicking Metastatic Malignant Hepatopancreatobiliary Tumors

T2 - Report of Two Cases and Review of the Literature

AU - Fong, Zhi Ven

AU - Wong, Joshua

AU - Maley, Warren R.

AU - Sandorfi, Nora

AU - Winter, Jordan M.

AU - Koniaris, Leonidas

AU - Sauter, Patricia K.

AU - Yeo, Charles J.

AU - Lavu, Harish

PY - 2012/6

Y1 - 2012/6

N2 - Introduction: Sarcoidosis is a multisystem chronic granulomatous disease found predominantly in the lungs and lymph nodes. Its pathologic hallmark is the presence of systemic non-caseating granulomas; however, a variation of this disease known as "sarcoid-like reaction" has been described in patients with underlying cancer. Report: Sarcoid-like reactions in patients with hepatopancreatobiliary (HPB) tumors are rare findings, with only 15 cases having been reported in the English language literature. These reactions can be found in local lymph nodes or in distant organs, and when present in patients with cancer, they can mimic metastatic disease on imaging, potentially resulting in incorrect cancer staging and management. Discussion: We describe two cases of patients with HPB tumors who had distant organ disease on cross-sectional imaging suspicious for metastases, which on further workup were found to be sarcoid-like reactions. We also discuss malignancy-induced sarcoid-like reactions and provide a review of the literature of sarcoid-like reactions in the setting of HPB tumors.

AB - Introduction: Sarcoidosis is a multisystem chronic granulomatous disease found predominantly in the lungs and lymph nodes. Its pathologic hallmark is the presence of systemic non-caseating granulomas; however, a variation of this disease known as "sarcoid-like reaction" has been described in patients with underlying cancer. Report: Sarcoid-like reactions in patients with hepatopancreatobiliary (HPB) tumors are rare findings, with only 15 cases having been reported in the English language literature. These reactions can be found in local lymph nodes or in distant organs, and when present in patients with cancer, they can mimic metastatic disease on imaging, potentially resulting in incorrect cancer staging and management. Discussion: We describe two cases of patients with HPB tumors who had distant organ disease on cross-sectional imaging suspicious for metastases, which on further workup were found to be sarcoid-like reactions. We also discuss malignancy-induced sarcoid-like reactions and provide a review of the literature of sarcoid-like reactions in the setting of HPB tumors.

UR - http://www.scopus.com/inward/record.url?scp=84861759769&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84861759769&partnerID=8YFLogxK

U2 - 10.1007/s11605-011-1820-3

DO - 10.1007/s11605-011-1820-3

M3 - Article

C2 - 22258875

AN - SCOPUS:84861759769

VL - 16

SP - 1245

EP - 1250

JO - Journal of Gastrointestinal Surgery

JF - Journal of Gastrointestinal Surgery

SN - 1091-255X

IS - 6

ER -