Sarcolemmal Enzymes Mediating β-Adrenergic Effects on the Heart

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Abstract

This chapter describes those enzyme systems localized to cardiac sarcolemma that are strongly suspected to mediate the β-adrenergic effects of catecholamines on the heart. The chapter focuses on recent, newer biochemical developments in the field that have been obtained with the use of highly purified cardiac sarcolemmal preparations isolated from mammalian myocardium and also refers to recent experimental observations made in other cardiac systems, which are likewise germane to the biochemical mechanism of action of the catecholamines. Several key steps along this reaction pathway are only poorly understood and much more work needs to be done. Future experimentation in this area will probably be directed toward a more detailed molecular characterization of β-adrenergic receptor-adenylate cyclase coupling in heart, elucidation of the role of soluble versus sarcolemmal pools of cyclic adenosine monophosphate (cAMP)-dependent protein kinase activity, and definitive identification and characterization of the sarcolemmal slow Ca2+ channel. The availability of a highly purified cardiac sarcolemmal preparation will be useful in future studies directed toward these goals.

Original languageEnglish (US)
Pages (from-to)11-41
Number of pages31
JournalCurrent Topics in Membranes and Transport
Volume25
Issue numberC
DOIs
StatePublished - Jan 1 1985

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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