Scattering anisotropy-weighted mesoscopic imaging

Zhengbin Xu, Ally Khan Somani, Young L. Kim

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

We report that when tissue images are formed via a small solid angle in the backward direction (i.e., back-directional gating), the image intensity is dominantly determined by tissue scattering anisotropy. Thus, this configuration allows for scattering anisotropy-weighted imaging that can provide an intrinsic contrast by capturing tissue structures and organizations. To demonstrate the immediate feasibility, we apply scattering anisotropyweighted imaging to tissue blocks including basal-cell carcinomas as a pilot study. The main feature of our imaging approach is the high sensitivity to tumor locations and the simplicity for large-area visualization. We further envision that scattering anisotropy-weighted imaging could potentially be used to visualize tissue microenvironments in a mesoscopic (between microscopic and macroscopic) imaging setting.

Original languageEnglish (US)
Article number090501
JournalJournal of Biomedical Optics
Volume17
Issue number9
DOIs
StatePublished - Sep 1 2012

Keywords

  • anisotropy
  • backscattering
  • mesoscopic imaging
  • tissue organization
  • tumor microenvironment

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics

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