SCCRO expression correlates with invasive progression in bronchioloalveolar carcinoma

Inderpal S. Sarkaria, Mimi Ceppa, Ronald A. Ghossein, Simon G. Talbot, Michael Hezel, Maria E. Dudas, Michael I. Ebright, Shaokun Chuai, Natalie Memoli, Ennapadam S. Venkatraman, Vincent A. Miller, Mark G. Kris, Maureen F. Zakowski, Valerie W. Rusch, Bhuvanesh Singh

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background Overexpression of squamous cell carcinoma-related oncogene (SCCRO) is associated with invasive progression and poor outcomes in non-small cell lung cancer. We assessed the role of SCCRO as a tumor marker in bronchioloalveolar carcinoma (BAC), a subtype of adenocarcinoma exhibiting evidence of histologic tumor progression. We hypothesized that SCCRO expression would correlate with invasive tumor phenotypes and worse survival in BAC. Methods We classified 150 tumors as pure BAC, BAC with focal invasion, or adenocarcinoma with BAC features. A tissue microarray was constructed from areas of benign lung, BAC, and invasive adenocarcinoma in these tumors. Squamous cell carcinoma-related oncogene expression was graded by immunohistochemistry from 0 to 3 (absent, low, moderate, or high), with positive SCCRO phenotype defined as grade 3. Squamous cell carcinoma-related oncogene specificity was determined by Wilcoxon rank test and area under the receiver-operator curve, survival by the Kaplan-Meier method, and correlation with prognostic factors by log-rank test. Results Of the 86.0% (129 of 150) of specimens suitable for analysis, positive SCCRO phenotype was seen in 16.3% (21 of 129) and was 100.0% specific for tumor versus benign tissue (area under receiver-operator curve, 0.92). Positive SCCRO phenotype was greater in tumors with increasing degrees of invasive histologic type (7.0% pure BAC, 13.6% BAC with focal invasion, and 28.6% adenocarcinoma with BAC features; p = 0.02). Low-level SCCRO expression was present in 83.9% (99 of 118) of benign tissues and correlated with tobacco use and poor survival (p = 0.05). Conclusions Squamous cell carcinoma-related oncogene is a marker of invasive tumor progression in BAC. Low-level expression in adjacent benign lung predicts worse survival, and may represent field cancerization or host-tumor effects.

Original languageEnglish (US)
Pages (from-to)1734-1741
Number of pages8
JournalAnnals of Thoracic Surgery
Volume78
Issue number5
DOIs
StatePublished - Nov 2004
Externally publishedYes

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Bronchiolo-Alveolar Adenocarcinoma
Oncogenes
Squamous Cell Carcinoma
Adenocarcinoma
Neoplasms
Phenotype
Tumor Biomarkers
Lung
Kaplan-Meier Estimate
Tobacco Use
Nonparametric Statistics
Non-Small Cell Lung Carcinoma
Immunohistochemistry

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Sarkaria, I. S., Ceppa, M., Ghossein, R. A., Talbot, S. G., Hezel, M., Dudas, M. E., ... Singh, B. (2004). SCCRO expression correlates with invasive progression in bronchioloalveolar carcinoma. Annals of Thoracic Surgery, 78(5), 1734-1741. https://doi.org/10.1016/j.athoracsur.2004.05.056

SCCRO expression correlates with invasive progression in bronchioloalveolar carcinoma. / Sarkaria, Inderpal S.; Ceppa, Mimi; Ghossein, Ronald A.; Talbot, Simon G.; Hezel, Michael; Dudas, Maria E.; Ebright, Michael I.; Chuai, Shaokun; Memoli, Natalie; Venkatraman, Ennapadam S.; Miller, Vincent A.; Kris, Mark G.; Zakowski, Maureen F.; Rusch, Valerie W.; Singh, Bhuvanesh.

In: Annals of Thoracic Surgery, Vol. 78, No. 5, 11.2004, p. 1734-1741.

Research output: Contribution to journalArticle

Sarkaria, IS, Ceppa, M, Ghossein, RA, Talbot, SG, Hezel, M, Dudas, ME, Ebright, MI, Chuai, S, Memoli, N, Venkatraman, ES, Miller, VA, Kris, MG, Zakowski, MF, Rusch, VW & Singh, B 2004, 'SCCRO expression correlates with invasive progression in bronchioloalveolar carcinoma', Annals of Thoracic Surgery, vol. 78, no. 5, pp. 1734-1741. https://doi.org/10.1016/j.athoracsur.2004.05.056
Sarkaria, Inderpal S. ; Ceppa, Mimi ; Ghossein, Ronald A. ; Talbot, Simon G. ; Hezel, Michael ; Dudas, Maria E. ; Ebright, Michael I. ; Chuai, Shaokun ; Memoli, Natalie ; Venkatraman, Ennapadam S. ; Miller, Vincent A. ; Kris, Mark G. ; Zakowski, Maureen F. ; Rusch, Valerie W. ; Singh, Bhuvanesh. / SCCRO expression correlates with invasive progression in bronchioloalveolar carcinoma. In: Annals of Thoracic Surgery. 2004 ; Vol. 78, No. 5. pp. 1734-1741.
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title = "SCCRO expression correlates with invasive progression in bronchioloalveolar carcinoma",
abstract = "Background Overexpression of squamous cell carcinoma-related oncogene (SCCRO) is associated with invasive progression and poor outcomes in non-small cell lung cancer. We assessed the role of SCCRO as a tumor marker in bronchioloalveolar carcinoma (BAC), a subtype of adenocarcinoma exhibiting evidence of histologic tumor progression. We hypothesized that SCCRO expression would correlate with invasive tumor phenotypes and worse survival in BAC. Methods We classified 150 tumors as pure BAC, BAC with focal invasion, or adenocarcinoma with BAC features. A tissue microarray was constructed from areas of benign lung, BAC, and invasive adenocarcinoma in these tumors. Squamous cell carcinoma-related oncogene expression was graded by immunohistochemistry from 0 to 3 (absent, low, moderate, or high), with positive SCCRO phenotype defined as grade 3. Squamous cell carcinoma-related oncogene specificity was determined by Wilcoxon rank test and area under the receiver-operator curve, survival by the Kaplan-Meier method, and correlation with prognostic factors by log-rank test. Results Of the 86.0{\%} (129 of 150) of specimens suitable for analysis, positive SCCRO phenotype was seen in 16.3{\%} (21 of 129) and was 100.0{\%} specific for tumor versus benign tissue (area under receiver-operator curve, 0.92). Positive SCCRO phenotype was greater in tumors with increasing degrees of invasive histologic type (7.0{\%} pure BAC, 13.6{\%} BAC with focal invasion, and 28.6{\%} adenocarcinoma with BAC features; p = 0.02). Low-level SCCRO expression was present in 83.9{\%} (99 of 118) of benign tissues and correlated with tobacco use and poor survival (p = 0.05). Conclusions Squamous cell carcinoma-related oncogene is a marker of invasive tumor progression in BAC. Low-level expression in adjacent benign lung predicts worse survival, and may represent field cancerization or host-tumor effects.",
author = "Sarkaria, {Inderpal S.} and Mimi Ceppa and Ghossein, {Ronald A.} and Talbot, {Simon G.} and Michael Hezel and Dudas, {Maria E.} and Ebright, {Michael I.} and Shaokun Chuai and Natalie Memoli and Venkatraman, {Ennapadam S.} and Miller, {Vincent A.} and Kris, {Mark G.} and Zakowski, {Maureen F.} and Rusch, {Valerie W.} and Bhuvanesh Singh",
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T1 - SCCRO expression correlates with invasive progression in bronchioloalveolar carcinoma

AU - Sarkaria, Inderpal S.

AU - Ceppa, Mimi

AU - Ghossein, Ronald A.

AU - Talbot, Simon G.

AU - Hezel, Michael

AU - Dudas, Maria E.

AU - Ebright, Michael I.

AU - Chuai, Shaokun

AU - Memoli, Natalie

AU - Venkatraman, Ennapadam S.

AU - Miller, Vincent A.

AU - Kris, Mark G.

AU - Zakowski, Maureen F.

AU - Rusch, Valerie W.

AU - Singh, Bhuvanesh

PY - 2004/11

Y1 - 2004/11

N2 - Background Overexpression of squamous cell carcinoma-related oncogene (SCCRO) is associated with invasive progression and poor outcomes in non-small cell lung cancer. We assessed the role of SCCRO as a tumor marker in bronchioloalveolar carcinoma (BAC), a subtype of adenocarcinoma exhibiting evidence of histologic tumor progression. We hypothesized that SCCRO expression would correlate with invasive tumor phenotypes and worse survival in BAC. Methods We classified 150 tumors as pure BAC, BAC with focal invasion, or adenocarcinoma with BAC features. A tissue microarray was constructed from areas of benign lung, BAC, and invasive adenocarcinoma in these tumors. Squamous cell carcinoma-related oncogene expression was graded by immunohistochemistry from 0 to 3 (absent, low, moderate, or high), with positive SCCRO phenotype defined as grade 3. Squamous cell carcinoma-related oncogene specificity was determined by Wilcoxon rank test and area under the receiver-operator curve, survival by the Kaplan-Meier method, and correlation with prognostic factors by log-rank test. Results Of the 86.0% (129 of 150) of specimens suitable for analysis, positive SCCRO phenotype was seen in 16.3% (21 of 129) and was 100.0% specific for tumor versus benign tissue (area under receiver-operator curve, 0.92). Positive SCCRO phenotype was greater in tumors with increasing degrees of invasive histologic type (7.0% pure BAC, 13.6% BAC with focal invasion, and 28.6% adenocarcinoma with BAC features; p = 0.02). Low-level SCCRO expression was present in 83.9% (99 of 118) of benign tissues and correlated with tobacco use and poor survival (p = 0.05). Conclusions Squamous cell carcinoma-related oncogene is a marker of invasive tumor progression in BAC. Low-level expression in adjacent benign lung predicts worse survival, and may represent field cancerization or host-tumor effects.

AB - Background Overexpression of squamous cell carcinoma-related oncogene (SCCRO) is associated with invasive progression and poor outcomes in non-small cell lung cancer. We assessed the role of SCCRO as a tumor marker in bronchioloalveolar carcinoma (BAC), a subtype of adenocarcinoma exhibiting evidence of histologic tumor progression. We hypothesized that SCCRO expression would correlate with invasive tumor phenotypes and worse survival in BAC. Methods We classified 150 tumors as pure BAC, BAC with focal invasion, or adenocarcinoma with BAC features. A tissue microarray was constructed from areas of benign lung, BAC, and invasive adenocarcinoma in these tumors. Squamous cell carcinoma-related oncogene expression was graded by immunohistochemistry from 0 to 3 (absent, low, moderate, or high), with positive SCCRO phenotype defined as grade 3. Squamous cell carcinoma-related oncogene specificity was determined by Wilcoxon rank test and area under the receiver-operator curve, survival by the Kaplan-Meier method, and correlation with prognostic factors by log-rank test. Results Of the 86.0% (129 of 150) of specimens suitable for analysis, positive SCCRO phenotype was seen in 16.3% (21 of 129) and was 100.0% specific for tumor versus benign tissue (area under receiver-operator curve, 0.92). Positive SCCRO phenotype was greater in tumors with increasing degrees of invasive histologic type (7.0% pure BAC, 13.6% BAC with focal invasion, and 28.6% adenocarcinoma with BAC features; p = 0.02). Low-level SCCRO expression was present in 83.9% (99 of 118) of benign tissues and correlated with tobacco use and poor survival (p = 0.05). Conclusions Squamous cell carcinoma-related oncogene is a marker of invasive tumor progression in BAC. Low-level expression in adjacent benign lung predicts worse survival, and may represent field cancerization or host-tumor effects.

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