School-located influenza vaccination reduces community risk for influenza and influenza-like illness emergency care visits

Cuc H. Tran, Jonathan D. Sugimoto, Juliet R.C. Pulliam, Kathleen A. Ryan, Paul D. Myers, Joan B. Castleman, Rell Doty, Jackie Johnson, Jim Stringfellow, Nadia Kovacevich, Joe Brew, Lai Ling Cheung, Brad Caron, Gloria Lipori, Chris Harle, Charles Alexer, Yang Yang, Ira M. Longini, M. Elizabeth Halloran, J. Glenn MorrisParker A. Small

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background: School-located influenza vaccination (SLIV) programs can substantially enhance the sub-optimal coverage achieved under existing delivery strategies. Randomized SLIV trials have shown these programs reduce laboratoryconfirmed influenza among both vaccinated and unvaccinated children. This work explores the effectiveness of a SLIV program in reducing the community risk of influenza and influenza-like illness (ILI) associated emergency care visits.

Methods: For the 2011/12 and 2012/13 influenza seasons, we estimated agegroup specific attack rates (AR) for ILI from routine surveillance and census data. Age-group specific SLIV program effectiveness was estimated as one minus the AR ratio for Alachua County versus two comparison regions: the 12 county region surrounding Alachua County, and all non-Alachua counties in Florida.

Results: Vaccination of , 50% of 5-17 year-olds in Alachua reduced their risk of ILI-associated visits, compared to the rest of Florida, by 79% (95% confidence interval: 70, 85) in 2011/12 and 71% (63, 77) in 2012/13. The greatest indirect effectiveness was observed among 0-4 year-olds, reducing AR by 89% (84, 93) in 2011/12 and 84% (79, 88) in 2012/13. Among all non-school age residents, the estimated indirect effectiveness was 60% (54, 65) and 36% (31, 41) for 2011/12 and 2012/13. The overall effectiveness among all age-groups was 65% (61, 70) and 46% (42, 50) for 2011/12 and 2012/13.

Conclusion: Wider implementation of SLIV programs can significantly reduce the influenza-associated public health burden in communities.

Original languageEnglish (US)
JournalPLoS One
Volume9
Issue number12
DOIs
StatePublished - Dec 9 2014
Externally publishedYes

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Emergency Medical Services
influenza
Human Influenza
Vaccination
vaccination
Public health
Age Groups
census data
Program Evaluation
Censuses
confidence interval
public health
Public Health
Confidence Intervals

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Tran, C. H., Sugimoto, J. D., Pulliam, J. R. C., Ryan, K. A., Myers, P. D., Castleman, J. B., ... Small, P. A. (2014). School-located influenza vaccination reduces community risk for influenza and influenza-like illness emergency care visits. PLoS One, 9(12). https://doi.org/10.1371/journal.pone.0114479

School-located influenza vaccination reduces community risk for influenza and influenza-like illness emergency care visits. / Tran, Cuc H.; Sugimoto, Jonathan D.; Pulliam, Juliet R.C.; Ryan, Kathleen A.; Myers, Paul D.; Castleman, Joan B.; Doty, Rell; Johnson, Jackie; Stringfellow, Jim; Kovacevich, Nadia; Brew, Joe; Cheung, Lai Ling; Caron, Brad; Lipori, Gloria; Harle, Chris; Alexer, Charles; Yang, Yang; Longini, Ira M.; Halloran, M. Elizabeth; Morris, J. Glenn; Small, Parker A.

In: PLoS One, Vol. 9, No. 12, 09.12.2014.

Research output: Contribution to journalArticle

Tran, CH, Sugimoto, JD, Pulliam, JRC, Ryan, KA, Myers, PD, Castleman, JB, Doty, R, Johnson, J, Stringfellow, J, Kovacevich, N, Brew, J, Cheung, LL, Caron, B, Lipori, G, Harle, C, Alexer, C, Yang, Y, Longini, IM, Halloran, ME, Morris, JG & Small, PA 2014, 'School-located influenza vaccination reduces community risk for influenza and influenza-like illness emergency care visits', PLoS One, vol. 9, no. 12. https://doi.org/10.1371/journal.pone.0114479
Tran, Cuc H. ; Sugimoto, Jonathan D. ; Pulliam, Juliet R.C. ; Ryan, Kathleen A. ; Myers, Paul D. ; Castleman, Joan B. ; Doty, Rell ; Johnson, Jackie ; Stringfellow, Jim ; Kovacevich, Nadia ; Brew, Joe ; Cheung, Lai Ling ; Caron, Brad ; Lipori, Gloria ; Harle, Chris ; Alexer, Charles ; Yang, Yang ; Longini, Ira M. ; Halloran, M. Elizabeth ; Morris, J. Glenn ; Small, Parker A. / School-located influenza vaccination reduces community risk for influenza and influenza-like illness emergency care visits. In: PLoS One. 2014 ; Vol. 9, No. 12.
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abstract = "Background: School-located influenza vaccination (SLIV) programs can substantially enhance the sub-optimal coverage achieved under existing delivery strategies. Randomized SLIV trials have shown these programs reduce laboratoryconfirmed influenza among both vaccinated and unvaccinated children. This work explores the effectiveness of a SLIV program in reducing the community risk of influenza and influenza-like illness (ILI) associated emergency care visits.Methods: For the 2011/12 and 2012/13 influenza seasons, we estimated agegroup specific attack rates (AR) for ILI from routine surveillance and census data. Age-group specific SLIV program effectiveness was estimated as one minus the AR ratio for Alachua County versus two comparison regions: the 12 county region surrounding Alachua County, and all non-Alachua counties in Florida.Results: Vaccination of , 50{\%} of 5-17 year-olds in Alachua reduced their risk of ILI-associated visits, compared to the rest of Florida, by 79{\%} (95{\%} confidence interval: 70, 85) in 2011/12 and 71{\%} (63, 77) in 2012/13. The greatest indirect effectiveness was observed among 0-4 year-olds, reducing AR by 89{\%} (84, 93) in 2011/12 and 84{\%} (79, 88) in 2012/13. Among all non-school age residents, the estimated indirect effectiveness was 60{\%} (54, 65) and 36{\%} (31, 41) for 2011/12 and 2012/13. The overall effectiveness among all age-groups was 65{\%} (61, 70) and 46{\%} (42, 50) for 2011/12 and 2012/13.Conclusion: Wider implementation of SLIV programs can significantly reduce the influenza-associated public health burden in communities.",
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AU - Sugimoto, Jonathan D.

AU - Pulliam, Juliet R.C.

AU - Ryan, Kathleen A.

AU - Myers, Paul D.

AU - Castleman, Joan B.

AU - Doty, Rell

AU - Johnson, Jackie

AU - Stringfellow, Jim

AU - Kovacevich, Nadia

AU - Brew, Joe

AU - Cheung, Lai Ling

AU - Caron, Brad

AU - Lipori, Gloria

AU - Harle, Chris

AU - Alexer, Charles

AU - Yang, Yang

AU - Longini, Ira M.

AU - Halloran, M. Elizabeth

AU - Morris, J. Glenn

AU - Small, Parker A.

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N2 - Background: School-located influenza vaccination (SLIV) programs can substantially enhance the sub-optimal coverage achieved under existing delivery strategies. Randomized SLIV trials have shown these programs reduce laboratoryconfirmed influenza among both vaccinated and unvaccinated children. This work explores the effectiveness of a SLIV program in reducing the community risk of influenza and influenza-like illness (ILI) associated emergency care visits.Methods: For the 2011/12 and 2012/13 influenza seasons, we estimated agegroup specific attack rates (AR) for ILI from routine surveillance and census data. Age-group specific SLIV program effectiveness was estimated as one minus the AR ratio for Alachua County versus two comparison regions: the 12 county region surrounding Alachua County, and all non-Alachua counties in Florida.Results: Vaccination of , 50% of 5-17 year-olds in Alachua reduced their risk of ILI-associated visits, compared to the rest of Florida, by 79% (95% confidence interval: 70, 85) in 2011/12 and 71% (63, 77) in 2012/13. The greatest indirect effectiveness was observed among 0-4 year-olds, reducing AR by 89% (84, 93) in 2011/12 and 84% (79, 88) in 2012/13. Among all non-school age residents, the estimated indirect effectiveness was 60% (54, 65) and 36% (31, 41) for 2011/12 and 2012/13. The overall effectiveness among all age-groups was 65% (61, 70) and 46% (42, 50) for 2011/12 and 2012/13.Conclusion: Wider implementation of SLIV programs can significantly reduce the influenza-associated public health burden in communities.

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