Sclerosing adenosis of the prostate gland: A lesion showing myoepithelial differentiation

David Grignon, J. Y. Ro, J. R. Srigley, P. Troncoso, A. K. Raymond, A. G. Ayala

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Sclerosing adenosis of the prostate is a rare lesion characterized by the proliferation of variably sized glands in a cellular stroma. We report light microscopic, immunohistochemical, and ultrastructural studies in 22 examples from 15 patients. Two cases were identified in 100 consecutive prostates embedded by a whole organ method, giving a prevalence of 2%. Antibodies directed against the following antigens were used: high-molecular-weight cytokeratin (CK(H); 34βE12); cytokeratin (CK; AE1/AE3), prostatic acid phosphatase (PAP), prostate-specific antigen (PSA), S-100 protein, muscle- specific actin (HHF35), and vimentin (Vim). Cells within the glandular component demonstrated positive reactivity for CK, CH(H), PSA, and PAP, indicating a prostatic epithelial origin. In addition, a distinct population of cells reacting for muscle-specific actin and S-100 protein was identified within this glandular element. Adequate material for ultrastructural study was available in five cases; all showed the presence of flattened cells located between the basement membrane and secretory epithelial cells, which had features typical for myoepithelial differentiation. Although the prostate gland does not normally contain myoepithelial cells, we have documented their consistent presence in this unusual lesion; we believe these cells arise by a metaplastic process from the prostatic basal cells.

Original languageEnglish (US)
Pages (from-to)383-391
Number of pages9
JournalAmerican Journal of Surgical Pathology
Volume16
Issue number4
StatePublished - 1992
Externally publishedYes

Fingerprint

Prostate
S100 Proteins
Prostate-Specific Antigen
Keratins
Actins
Vimentin
Basement Membrane
Muscle Cells
Molecular Weight
Epithelial Cells
Light
Antigens
Muscles
Antibodies
Population
prostatic acid phosphatase

Keywords

  • Myoepithelial cells
  • Prostate
  • Sclerosing adenosis

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

Cite this

Grignon, D., Ro, J. Y., Srigley, J. R., Troncoso, P., Raymond, A. K., & Ayala, A. G. (1992). Sclerosing adenosis of the prostate gland: A lesion showing myoepithelial differentiation. American Journal of Surgical Pathology, 16(4), 383-391.

Sclerosing adenosis of the prostate gland : A lesion showing myoepithelial differentiation. / Grignon, David; Ro, J. Y.; Srigley, J. R.; Troncoso, P.; Raymond, A. K.; Ayala, A. G.

In: American Journal of Surgical Pathology, Vol. 16, No. 4, 1992, p. 383-391.

Research output: Contribution to journalArticle

Grignon, D, Ro, JY, Srigley, JR, Troncoso, P, Raymond, AK & Ayala, AG 1992, 'Sclerosing adenosis of the prostate gland: A lesion showing myoepithelial differentiation', American Journal of Surgical Pathology, vol. 16, no. 4, pp. 383-391.
Grignon, David ; Ro, J. Y. ; Srigley, J. R. ; Troncoso, P. ; Raymond, A. K. ; Ayala, A. G. / Sclerosing adenosis of the prostate gland : A lesion showing myoepithelial differentiation. In: American Journal of Surgical Pathology. 1992 ; Vol. 16, No. 4. pp. 383-391.
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