Sclerosing Cholangitis–Like Changes on Magnetic Resonance Cholangiography in Patients With Drug Induced Liver Injury

Jawad Ahmad, Simona Rossi, Shuchi K. Rodgers, Marwan Ghabril, Robert J. Fontana, Andrew Stolz, Paul H. Hayashi, Huiman Barnhart, David E. Kleiner, Einar S. Bjornsson

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Abstract

Drug-induced liver injury can lead to changes of the biliary tree that resemble sclerosing cholangitis. These changes can be seen on magnetic resonance cholangiopancreatography. Idiosyncratic drug-induced liver injury (DILI) has a variable presentation including cholestatic liver injury, 1 in which case magnetic resonance imaging (MRI) is often performed to exclude pancreaticobiliary causes of obstruction. Sclerosing cholangitis (SC)–like changes on imaging have been described anecdotally with DILI. 2,3 A recent study of 25 consecutive, unselected DILI patients found that 10% had SC-like changes on magnetic resonance cholangiopancreatography (MRCP). 4 The aim of the current study was to identify the clinical features of patients enrolled in the U.S. Drug Induced Liver Injury Network (DILIN) prospective study who had SC-like changes on MRCP.

Original languageEnglish (US)
Pages (from-to)789-790
Number of pages2
JournalClinical Gastroenterology and Hepatology
Volume17
Issue number4
DOIs
StatePublished - Mar 2019

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ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

Ahmad, J., Rossi, S., Rodgers, S. K., Ghabril, M., Fontana, R. J., Stolz, A., Hayashi, P. H., Barnhart, H., Kleiner, D. E., & Bjornsson, E. S. (2019). Sclerosing Cholangitis–Like Changes on Magnetic Resonance Cholangiography in Patients With Drug Induced Liver Injury. Clinical Gastroenterology and Hepatology, 17(4), 789-790. https://doi.org/10.1016/j.cgh.2018.06.035