Screening for brain aneurysm in the Familial Intracranial Aneurysm study: Frequency and predictors of lesion detection

Robert D. Brown, John Huston, Richard Hornung, Tatiana Foroud, David F. Kallmes, Dawn Kleindorfer, Irene Meissner, Daniel Woo, Laura Sauerbeck, Joseph Broderick

Research output: Contribution to journalArticle

56 Scopus citations

Abstract

Object. Approximately 20% of patients with an intracranial saccular aneurysm report a family history of intracranial aneurysm (IA) or subarachnoid hemorrhage. A better understanding of predictors of aneurysm detection in familial IA may allow more targeted aneurysm screening strategies. Methods. The Familial Intracranial Aneurysm (FIA) study is a multicenter study, in which the primary objective is to define the susceptibility genes related to the formation of IA. First-degree relatives (FDRs) of those affected with IA are offered screening with magnetic resonance (MR) angiography if they were previously unaffected, are ≥ 30 years of age, and have a history of smoking and/or hypertension. Independent predictors of aneurysm detection on MR angiography were determined using the generalized estimating equation version of logistic regression. Results. Among the first 303 patients screened with MR angiography, 58 (19.1%) had at least 1 IA, including 24% of women and 11.7% of men. Ten (17.2%) of 58 affected patients had multiple aneurysms. Independent predictors of aneurysm detection included female sex (odds ratio [OR] 2.46, p = 0.001), pack-years of cigarette smoking (OR 3.24 for 20 pack-years of cigarette smoking compared with never having smoked, p < 0.001), and duration of hypertension (OR 1.26 comparing those with 10 years of hypertension to those with no hypertension, p = 0.006). Conclusions. In the FIA study, among the affected patients' FDRs who are > 30 years of age, those who are women or who have a history of smoking or hypertension are at increased risk of suffering an IA and should be strongly considered for screening.

Original languageEnglish (US)
Pages (from-to)1132-1138
Number of pages7
JournalJournal of neurosurgery
Volume108
Issue number6
DOIs
StatePublished - Jun 1 2008

Keywords

  • Familial aneurysm
  • Genetics
  • Intracranial aneurysm
  • Magnetic resonance angiography
  • Screening study

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Screening for brain aneurysm in the Familial Intracranial Aneurysm study: Frequency and predictors of lesion detection'. Together they form a unique fingerprint.

  • Cite this

    Brown, R. D., Huston, J., Hornung, R., Foroud, T., Kallmes, D. F., Kleindorfer, D., Meissner, I., Woo, D., Sauerbeck, L., & Broderick, J. (2008). Screening for brain aneurysm in the Familial Intracranial Aneurysm study: Frequency and predictors of lesion detection. Journal of neurosurgery, 108(6), 1132-1138. https://doi.org/10.3171/JNS/2008/108/6/1132