Screening for brain aneurysm in the Familial Intracranial Aneurysm study: Frequency and predictors of lesion detection

Robert D. Brown, John Huston, Richard Hornung, Tatiana Foroud, David F. Kallmes, Dawn Kleindorfer, Irene Meissner, Daniel Woo, Laura Sauerbeck, Joseph Broderick

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Object. Approximately 20% of patients with an intracranial saccular aneurysm report a family history of intracranial aneurysm (IA) or subarachnoid hemorrhage. A better understanding of predictors of aneurysm detection in familial IA may allow more targeted aneurysm screening strategies. Methods. The Familial Intracranial Aneurysm (FIA) study is a multicenter study, in which the primary objective is to define the susceptibility genes related to the formation of IA. First-degree relatives (FDRs) of those affected with IA are offered screening with magnetic resonance (MR) angiography if they were previously unaffected, are ≥ 30 years of age, and have a history of smoking and/or hypertension. Independent predictors of aneurysm detection on MR angiography were determined using the generalized estimating equation version of logistic regression. Results. Among the first 303 patients screened with MR angiography, 58 (19.1%) had at least 1 IA, including 24% of women and 11.7% of men. Ten (17.2%) of 58 affected patients had multiple aneurysms. Independent predictors of aneurysm detection included female sex (odds ratio [OR] 2.46, p = 0.001), pack-years of cigarette smoking (OR 3.24 for 20 pack-years of cigarette smoking compared with never having smoked, p < 0.001), and duration of hypertension (OR 1.26 comparing those with 10 years of hypertension to those with no hypertension, p = 0.006). Conclusions. In the FIA study, among the affected patients' FDRs who are > 30 years of age, those who are women or who have a history of smoking or hypertension are at increased risk of suffering an IA and should be strongly considered for screening.

Original languageEnglish
Pages (from-to)1132-1138
Number of pages7
JournalJournal of Neurosurgery
Volume108
Issue number6
DOIs
StatePublished - Jun 2008

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Intracranial Aneurysm
Aneurysm
Magnetic Resonance Angiography
Smoking
Odds Ratio
Hypertension
Intracranial Hemorrhages
Sex Ratio
Subarachnoid Hemorrhage
Multicenter Studies
Logistic Models
Genes

Keywords

  • Familial aneurysm
  • Genetics
  • Intracranial aneurysm
  • Magnetic resonance angiography
  • Screening study

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Screening for brain aneurysm in the Familial Intracranial Aneurysm study : Frequency and predictors of lesion detection. / Brown, Robert D.; Huston, John; Hornung, Richard; Foroud, Tatiana; Kallmes, David F.; Kleindorfer, Dawn; Meissner, Irene; Woo, Daniel; Sauerbeck, Laura; Broderick, Joseph.

In: Journal of Neurosurgery, Vol. 108, No. 6, 06.2008, p. 1132-1138.

Research output: Contribution to journalArticle

Brown, RD, Huston, J, Hornung, R, Foroud, T, Kallmes, DF, Kleindorfer, D, Meissner, I, Woo, D, Sauerbeck, L & Broderick, J 2008, 'Screening for brain aneurysm in the Familial Intracranial Aneurysm study: Frequency and predictors of lesion detection', Journal of Neurosurgery, vol. 108, no. 6, pp. 1132-1138. https://doi.org/10.3171/JNS/2008/108/6/1132
Brown, Robert D. ; Huston, John ; Hornung, Richard ; Foroud, Tatiana ; Kallmes, David F. ; Kleindorfer, Dawn ; Meissner, Irene ; Woo, Daniel ; Sauerbeck, Laura ; Broderick, Joseph. / Screening for brain aneurysm in the Familial Intracranial Aneurysm study : Frequency and predictors of lesion detection. In: Journal of Neurosurgery. 2008 ; Vol. 108, No. 6. pp. 1132-1138.
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abstract = "Object. Approximately 20{\%} of patients with an intracranial saccular aneurysm report a family history of intracranial aneurysm (IA) or subarachnoid hemorrhage. A better understanding of predictors of aneurysm detection in familial IA may allow more targeted aneurysm screening strategies. Methods. The Familial Intracranial Aneurysm (FIA) study is a multicenter study, in which the primary objective is to define the susceptibility genes related to the formation of IA. First-degree relatives (FDRs) of those affected with IA are offered screening with magnetic resonance (MR) angiography if they were previously unaffected, are ≥ 30 years of age, and have a history of smoking and/or hypertension. Independent predictors of aneurysm detection on MR angiography were determined using the generalized estimating equation version of logistic regression. Results. Among the first 303 patients screened with MR angiography, 58 (19.1{\%}) had at least 1 IA, including 24{\%} of women and 11.7{\%} of men. Ten (17.2{\%}) of 58 affected patients had multiple aneurysms. Independent predictors of aneurysm detection included female sex (odds ratio [OR] 2.46, p = 0.001), pack-years of cigarette smoking (OR 3.24 for 20 pack-years of cigarette smoking compared with never having smoked, p < 0.001), and duration of hypertension (OR 1.26 comparing those with 10 years of hypertension to those with no hypertension, p = 0.006). Conclusions. In the FIA study, among the affected patients' FDRs who are > 30 years of age, those who are women or who have a history of smoking or hypertension are at increased risk of suffering an IA and should be strongly considered for screening.",
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T1 - Screening for brain aneurysm in the Familial Intracranial Aneurysm study

T2 - Frequency and predictors of lesion detection

AU - Brown, Robert D.

AU - Huston, John

AU - Hornung, Richard

AU - Foroud, Tatiana

AU - Kallmes, David F.

AU - Kleindorfer, Dawn

AU - Meissner, Irene

AU - Woo, Daniel

AU - Sauerbeck, Laura

AU - Broderick, Joseph

PY - 2008/6

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N2 - Object. Approximately 20% of patients with an intracranial saccular aneurysm report a family history of intracranial aneurysm (IA) or subarachnoid hemorrhage. A better understanding of predictors of aneurysm detection in familial IA may allow more targeted aneurysm screening strategies. Methods. The Familial Intracranial Aneurysm (FIA) study is a multicenter study, in which the primary objective is to define the susceptibility genes related to the formation of IA. First-degree relatives (FDRs) of those affected with IA are offered screening with magnetic resonance (MR) angiography if they were previously unaffected, are ≥ 30 years of age, and have a history of smoking and/or hypertension. Independent predictors of aneurysm detection on MR angiography were determined using the generalized estimating equation version of logistic regression. Results. Among the first 303 patients screened with MR angiography, 58 (19.1%) had at least 1 IA, including 24% of women and 11.7% of men. Ten (17.2%) of 58 affected patients had multiple aneurysms. Independent predictors of aneurysm detection included female sex (odds ratio [OR] 2.46, p = 0.001), pack-years of cigarette smoking (OR 3.24 for 20 pack-years of cigarette smoking compared with never having smoked, p < 0.001), and duration of hypertension (OR 1.26 comparing those with 10 years of hypertension to those with no hypertension, p = 0.006). Conclusions. In the FIA study, among the affected patients' FDRs who are > 30 years of age, those who are women or who have a history of smoking or hypertension are at increased risk of suffering an IA and should be strongly considered for screening.

AB - Object. Approximately 20% of patients with an intracranial saccular aneurysm report a family history of intracranial aneurysm (IA) or subarachnoid hemorrhage. A better understanding of predictors of aneurysm detection in familial IA may allow more targeted aneurysm screening strategies. Methods. The Familial Intracranial Aneurysm (FIA) study is a multicenter study, in which the primary objective is to define the susceptibility genes related to the formation of IA. First-degree relatives (FDRs) of those affected with IA are offered screening with magnetic resonance (MR) angiography if they were previously unaffected, are ≥ 30 years of age, and have a history of smoking and/or hypertension. Independent predictors of aneurysm detection on MR angiography were determined using the generalized estimating equation version of logistic regression. Results. Among the first 303 patients screened with MR angiography, 58 (19.1%) had at least 1 IA, including 24% of women and 11.7% of men. Ten (17.2%) of 58 affected patients had multiple aneurysms. Independent predictors of aneurysm detection included female sex (odds ratio [OR] 2.46, p = 0.001), pack-years of cigarette smoking (OR 3.24 for 20 pack-years of cigarette smoking compared with never having smoked, p < 0.001), and duration of hypertension (OR 1.26 comparing those with 10 years of hypertension to those with no hypertension, p = 0.006). Conclusions. In the FIA study, among the affected patients' FDRs who are > 30 years of age, those who are women or who have a history of smoking or hypertension are at increased risk of suffering an IA and should be strongly considered for screening.

KW - Familial aneurysm

KW - Genetics

KW - Intracranial aneurysm

KW - Magnetic resonance angiography

KW - Screening study

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