Screening Sigmoidoscopy and Colorectal Cancer

William M. Tierney, Joe V. Selby, Gary D. Friedman, Charles P. Quesenberry, Noel S. Weiss

Research output: Contribution to journalLetter


To the Editor: The case–control study by Selby et al. (March 5 issue)* on the effect of screening sigmoidoscopy on mortality from rectosigmoid carcinoma was interesting to me because of my previous skepticism about the benefits of the procedure, given its costs and discomfort. The results are impressive, but I have one question: How does sigmoidoscopy exert this protective effect? Sigmoidoscopy is not a therapy for established cancer; therefore, for it to affect mortality from rectosigmoid carcinoma, it must lead to the excision of small malignant or premalignant lesions. However, the number of adenomatous polyps identified in the case subjects…

Original languageEnglish (US)
Number of pages1
JournalNew England Journal of Medicine
Issue number6
StatePublished - Aug 6 1992

ASJC Scopus subject areas

  • Medicine(all)

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    Tierney, W. M., Selby, J. V., Friedman, G. D., Quesenberry, C. P., & Weiss, N. S. (1992). Screening Sigmoidoscopy and Colorectal Cancer. New England Journal of Medicine, 327(6).