Searching for hemostatic modifier genes affecting the phenotype of mice with very low levels of FVII

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5 Scopus citations

Abstract

FVIItTA/- mice are heterozygous for the FVII- null allele and a gene-targeted allele expressing very low levels of FVII. Approximately half the FVIItTA/- in a mixed C57Bl/6:129x1/SVJ background survive much longer than mice in a C57Bl/6 background, suggesting that genetic background affects the survival of mice expressing very low levels of FVII. A lineage of long-term surviving FVIItTA/- mice in a predominantly C57Bl/6 background was generated by selecting 16 weeks or older FVIItTA/- males and breeding them with C57Bl/6 FVII+/- females. It is postulated that these mice maintain 129x1/SVJ alleles at putative hemostatic modifier loci necessary for the survival of mice expressing very low levels of FVII. A SNP genomic scan was performed on DNA from long-term surviving FVIItTA/- mice. The scan identified 8 regions enriched for 129x1/SVJ sequences that might contain putative hemostatic modifier genes.

Original languageEnglish (US)
Pages (from-to)131-134
Number of pages4
JournalBlood Cells, Molecules, and Diseases
Volume36
Issue number2
DOIs
StatePublished - Mar 1 2006

Keywords

  • Factor VII
  • Hemostasis
  • Modifier genes
  • Quantitative traits
  • SNPs
  • Strain differences

ASJC Scopus subject areas

  • Molecular Biology
  • Molecular Medicine
  • Hematology

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