Secondary neoplasms of the urinary system and male genital organs

Doriana Morichetti, Roberta Mazzucchelli, Antonio Lopez-Beltran, Liang Cheng, Marina Scarpelli, Ziya Kirkali, Francesco Montorsi, Rodolfo Montironi

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

BACKGROUND AND AIMS In this review we discuss those secondary tumours involving the urinary system and male genital organs that can pose differential diagnostic difficulties with primary lesions, and highlight morphological and ancillary features that could be helpful in reaching a proper assignment of primary origin. materials AND METHODS Based on MEDLINE database searches all reports of secondary tumours involving the urinary system (kidney and bladder) and male genital organs (prostate, testis and penis) were examined. RESULTS and discussion Involvement by a secondary tumour occurs either as a metastasis or by direct extension. Among non-genitourinary primary sites, colorectal, pulmonary, skin (melanoma) and breast are the most common contributors. Secondary spread from a genitourinary site primary tumour to another genitourinary organ occurs most frequently between the prostate and urinary bladder, given the intimate topographic proximity of the two. The prognosis is very poor, as the secondary tumour usually occurs in patients with carcinoma in the late stages. Few secondary tumours have distinctive histological and immunohistochemical features, making it difficult to make the appropriate diagnosis. Hence, knowledge of the history and clinical setting are particularly important in these cases. CONCLUSION The urinary system and male genital organs are not common sites for secondary tumours. They often go either undiagnosed or misdiagnosed in the clinical follow-up of patients with cancer. Accurate diagnosis is essential because of differing therapeutic approaches compared with a primary neoplasm.

Original languageEnglish
Pages (from-to)770-776
Number of pages7
JournalBJU International
Volume104
Issue number6
DOIs
StatePublished - Sep 2009

Fingerprint

Male Genitalia
Neoplasms
Prostate
Urinary Bladder
Penis
Diagnostic Errors
MEDLINE
Testis
Melanoma
Breast
History
Databases
Neoplasm Metastasis
Carcinoma
Kidney

Keywords

  • Male genital organs
  • Metastasis
  • Secondary tumours
  • Urinary system

ASJC Scopus subject areas

  • Urology

Cite this

Morichetti, D., Mazzucchelli, R., Lopez-Beltran, A., Cheng, L., Scarpelli, M., Kirkali, Z., ... Montironi, R. (2009). Secondary neoplasms of the urinary system and male genital organs. BJU International, 104(6), 770-776. https://doi.org/10.1111/j.1464-410X.2009.08746.x

Secondary neoplasms of the urinary system and male genital organs. / Morichetti, Doriana; Mazzucchelli, Roberta; Lopez-Beltran, Antonio; Cheng, Liang; Scarpelli, Marina; Kirkali, Ziya; Montorsi, Francesco; Montironi, Rodolfo.

In: BJU International, Vol. 104, No. 6, 09.2009, p. 770-776.

Research output: Contribution to journalArticle

Morichetti, D, Mazzucchelli, R, Lopez-Beltran, A, Cheng, L, Scarpelli, M, Kirkali, Z, Montorsi, F & Montironi, R 2009, 'Secondary neoplasms of the urinary system and male genital organs', BJU International, vol. 104, no. 6, pp. 770-776. https://doi.org/10.1111/j.1464-410X.2009.08746.x
Morichetti D, Mazzucchelli R, Lopez-Beltran A, Cheng L, Scarpelli M, Kirkali Z et al. Secondary neoplasms of the urinary system and male genital organs. BJU International. 2009 Sep;104(6):770-776. https://doi.org/10.1111/j.1464-410X.2009.08746.x
Morichetti, Doriana ; Mazzucchelli, Roberta ; Lopez-Beltran, Antonio ; Cheng, Liang ; Scarpelli, Marina ; Kirkali, Ziya ; Montorsi, Francesco ; Montironi, Rodolfo. / Secondary neoplasms of the urinary system and male genital organs. In: BJU International. 2009 ; Vol. 104, No. 6. pp. 770-776.
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