Secretion of nizatidine into human breast milk after single and multiple doses

Boyd D. Obermeyer, Richard F. Bergstrom, John T. Callaghan, Mary Pat Knadler, Alan Golichowski, Alan Rubin

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Disposition of the H,-receptor antagonist nizatidine was studied in serum, urine, and breast milk. Five lactating women and five nonlactating women participated; the disposition of nizatidine was studied in three of the lactating women. Single and multiple doses of 150 mg nizatidine were administered orally. The disposition of nizatidine (half-life, 1 1 2 hours; apparent serum clearance, 40 L/hr; renal clearance, 27 L/hr; and apparent volume of distribution, 1.4 L/kg) was similar in lactating and nonlactating women. These pharmacokinetic results were analogous to observations for men in other studies. Nizatidine breast milk concentrations were directly proportional to corresponding serum concentrations. On average, 96 μg nizatidine, less than 0.1% of the maternal dose, was secreted into milk during a 12-hour interval after either single or multiple doses.

Original languageEnglish (US)
Pages (from-to)724-730
Number of pages7
JournalClinical Pharmacology and Therapeutics
Volume47
Issue number6
DOIs
StatePublished - Jun 1990

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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