Segmental expression of aggrecan in the non-segmented perinotochordal sheath underlies normal segmentation of the vertebral column

Justin Bundy, Rhonda Rogers, Stanley Hoffman, Simon J. Conway

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

The embryonic vertebral column is derived from the unsegmented axial mesenchyme surrounding the notochord, and its development and differentiation are influenced by the notochord. The role of cartilage in determining the ultimate pattern of the segmental skeleton has been well documented, but a gene whose segmental expression corresponds to the pattern of the developing skeleton has yet to be identified. We show that chick aggrecan is initially expressed within the entire length of the notochord, and as development proceeds, aggrecan expression becomes restricted to the surrounding perinotochordal sheath in a segmental pattern, mirroring the differentiated somite pattern.

Original languageEnglish (US)
Pages (from-to)213-217
Number of pages5
JournalMechanisms of Development
Volume79
Issue number1-2
DOIs
StatePublished - Dec 1 1998
Externally publishedYes

Keywords

  • Aggrecan
  • Cartilage formation
  • Chick
  • Notochord
  • Perinotochordal sheath
  • Segmental skeleton

ASJC Scopus subject areas

  • Embryology
  • Developmental Biology

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