Seizure characteristics and control after microsurgical resection of supratentorial cerebral cavernous malformations

Edward F. Chang, Rodney A. Gabriel, Matthew B. Potts, Paul A. Garcia, Nicholas Barbaro, Michael T. Lawton

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

OBJECTIVE: The optimal management of seizures associated with cerebral cavernous malformations (CCMs) is unclear. The aim of this study was to determine the efficacy of surgery in the management of CCM-associated seizures. METHODS: We conducted a retrospective review with follow-up of 164 patients who underwent microsurgical resection of supratentorial CCMs. Clinical and radiographic data were collected and then analyzed to determine predictors of developing epilepsy and predictors of postoperative seizure control after microsurgical resection. RESULTS: Of the patients, 61.5% presented with seizures, and 34.7% had clinically defined epilepsy. The development of epilepsy was associated with CCMs located in the temporal lobe and the absence of symptomatic hemorrhage. After microsurgical resection in 44 patients with intractable epilepsy, 72.7% were completely seizure-free (Engel class 1), 11.4% had rare seizures (Engel class 2), 4.5% had meaningful improvement (Engel class 3), and 11.4% had no improvement (Engel class 4). Predictors of complete seizure freedom were gross total resection, smaller CCMs, and the absence of secondary generalized seizures (94% of patients were seizure-free with all 3 predictors). CONCLUSION: Surgery is a safe and effective treatment for seizures associated with CCMs.

Original languageEnglish (US)
Pages (from-to)31-37
Number of pages7
JournalNeurosurgery
Volume65
Issue number1
DOIs
StatePublished - Jul 2009
Externally publishedYes

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Central Nervous System Cavernous Hemangioma
Seizures
Epilepsy
Temporal Lobe

Keywords

  • Cavernous malformation
  • Engel score
  • Epilepsy electrocorticography
  • Microsurgery

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Seizure characteristics and control after microsurgical resection of supratentorial cerebral cavernous malformations. / Chang, Edward F.; Gabriel, Rodney A.; Potts, Matthew B.; Garcia, Paul A.; Barbaro, Nicholas; Lawton, Michael T.

In: Neurosurgery, Vol. 65, No. 1, 07.2009, p. 31-37.

Research output: Contribution to journalArticle

Chang, Edward F. ; Gabriel, Rodney A. ; Potts, Matthew B. ; Garcia, Paul A. ; Barbaro, Nicholas ; Lawton, Michael T. / Seizure characteristics and control after microsurgical resection of supratentorial cerebral cavernous malformations. In: Neurosurgery. 2009 ; Vol. 65, No. 1. pp. 31-37.
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