Seizure recurrence risk following a first seizure in neurologically normal children

Todd M. Arthur, Ton J. DeGrauw, Cynthia S. Johnson, Susan Perkins, Andrew Kalnin, Joan K. Austin, David Dunn

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Purpose: To define seizure recurrence rates in normal children who had had a single seizure and to define electroencephalography (EEG) or magnetic resonance imaging (MRI) utility in predicting seizure recurrence. Methods: We studied 150 children (6 to 14 years) with a first afebrile, unprovoked seizure. Inclusion criteria were: Normal physical and neurological examination, undergone EEG and MRI studies of the brain, and followed for at least 27 months. These children participated in an ongoing prospective study of new onset seizures in childhood. Results: The seizure recurrence rate was 66.4%. An abnormal EEG had no association with seizure recurrence at 9, 18, or 27 months (p = 0.1806, p = 0.2792, and p = 0.2379, respectively). A "significant" MRI abnormality, which occurred in 16.0% of patients, was associated with an increased seizure recurrence risk at 9 months (p = 0.0389) but not at 18 or 27 months. Discussion: EEG findings poorly predict recurrence after a single seizure. The high rate of MRI abnormalities suggests that MRI may need consideration as a routine test to evaluate epilepsy in normal children.

Original languageEnglish
Pages (from-to)1950-1954
Number of pages5
JournalEpilepsia
Volume49
Issue number11
DOIs
StatePublished - Nov 2008

Fingerprint

Seizures
Recurrence
Magnetic Resonance Imaging
Electroencephalography
Epilepsy
Neurologic Examination
Physical Examination
Prospective Studies
Brain

Keywords

  • Children
  • EEG
  • Epilepsy
  • MRI

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Seizure recurrence risk following a first seizure in neurologically normal children. / Arthur, Todd M.; DeGrauw, Ton J.; Johnson, Cynthia S.; Perkins, Susan; Kalnin, Andrew; Austin, Joan K.; Dunn, David.

In: Epilepsia, Vol. 49, No. 11, 11.2008, p. 1950-1954.

Research output: Contribution to journalArticle

Arthur, Todd M. ; DeGrauw, Ton J. ; Johnson, Cynthia S. ; Perkins, Susan ; Kalnin, Andrew ; Austin, Joan K. ; Dunn, David. / Seizure recurrence risk following a first seizure in neurologically normal children. In: Epilepsia. 2008 ; Vol. 49, No. 11. pp. 1950-1954.
@article{d1297565940b4f239222bdbe2555cdf8,
title = "Seizure recurrence risk following a first seizure in neurologically normal children",
abstract = "Purpose: To define seizure recurrence rates in normal children who had had a single seizure and to define electroencephalography (EEG) or magnetic resonance imaging (MRI) utility in predicting seizure recurrence. Methods: We studied 150 children (6 to 14 years) with a first afebrile, unprovoked seizure. Inclusion criteria were: Normal physical and neurological examination, undergone EEG and MRI studies of the brain, and followed for at least 27 months. These children participated in an ongoing prospective study of new onset seizures in childhood. Results: The seizure recurrence rate was 66.4{\%}. An abnormal EEG had no association with seizure recurrence at 9, 18, or 27 months (p = 0.1806, p = 0.2792, and p = 0.2379, respectively). A {"}significant{"} MRI abnormality, which occurred in 16.0{\%} of patients, was associated with an increased seizure recurrence risk at 9 months (p = 0.0389) but not at 18 or 27 months. Discussion: EEG findings poorly predict recurrence after a single seizure. The high rate of MRI abnormalities suggests that MRI may need consideration as a routine test to evaluate epilepsy in normal children.",
keywords = "Children, EEG, Epilepsy, MRI",
author = "Arthur, {Todd M.} and DeGrauw, {Ton J.} and Johnson, {Cynthia S.} and Susan Perkins and Andrew Kalnin and Austin, {Joan K.} and David Dunn",
year = "2008",
month = "11",
doi = "10.1111/j.1528-1167.2008.01775.x",
language = "English",
volume = "49",
pages = "1950--1954",
journal = "Epilepsia",
issn = "0013-9580",
publisher = "Wiley-Blackwell",
number = "11",

}

TY - JOUR

T1 - Seizure recurrence risk following a first seizure in neurologically normal children

AU - Arthur, Todd M.

AU - DeGrauw, Ton J.

AU - Johnson, Cynthia S.

AU - Perkins, Susan

AU - Kalnin, Andrew

AU - Austin, Joan K.

AU - Dunn, David

PY - 2008/11

Y1 - 2008/11

N2 - Purpose: To define seizure recurrence rates in normal children who had had a single seizure and to define electroencephalography (EEG) or magnetic resonance imaging (MRI) utility in predicting seizure recurrence. Methods: We studied 150 children (6 to 14 years) with a first afebrile, unprovoked seizure. Inclusion criteria were: Normal physical and neurological examination, undergone EEG and MRI studies of the brain, and followed for at least 27 months. These children participated in an ongoing prospective study of new onset seizures in childhood. Results: The seizure recurrence rate was 66.4%. An abnormal EEG had no association with seizure recurrence at 9, 18, or 27 months (p = 0.1806, p = 0.2792, and p = 0.2379, respectively). A "significant" MRI abnormality, which occurred in 16.0% of patients, was associated with an increased seizure recurrence risk at 9 months (p = 0.0389) but not at 18 or 27 months. Discussion: EEG findings poorly predict recurrence after a single seizure. The high rate of MRI abnormalities suggests that MRI may need consideration as a routine test to evaluate epilepsy in normal children.

AB - Purpose: To define seizure recurrence rates in normal children who had had a single seizure and to define electroencephalography (EEG) or magnetic resonance imaging (MRI) utility in predicting seizure recurrence. Methods: We studied 150 children (6 to 14 years) with a first afebrile, unprovoked seizure. Inclusion criteria were: Normal physical and neurological examination, undergone EEG and MRI studies of the brain, and followed for at least 27 months. These children participated in an ongoing prospective study of new onset seizures in childhood. Results: The seizure recurrence rate was 66.4%. An abnormal EEG had no association with seizure recurrence at 9, 18, or 27 months (p = 0.1806, p = 0.2792, and p = 0.2379, respectively). A "significant" MRI abnormality, which occurred in 16.0% of patients, was associated with an increased seizure recurrence risk at 9 months (p = 0.0389) but not at 18 or 27 months. Discussion: EEG findings poorly predict recurrence after a single seizure. The high rate of MRI abnormalities suggests that MRI may need consideration as a routine test to evaluate epilepsy in normal children.

KW - Children

KW - EEG

KW - Epilepsy

KW - MRI

UR - http://www.scopus.com/inward/record.url?scp=55349114695&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=55349114695&partnerID=8YFLogxK

U2 - 10.1111/j.1528-1167.2008.01775.x

DO - 10.1111/j.1528-1167.2008.01775.x

M3 - Article

C2 - 19154398

AN - SCOPUS:55349114695

VL - 49

SP - 1950

EP - 1954

JO - Epilepsia

JF - Epilepsia

SN - 0013-9580

IS - 11

ER -