Seizures as an early symptom of autosomal dominant Alzheimer's disease

Dominantly Inherited Alzheimer Network

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Our objective was to assess the reported history of seizures in cognitively asymptomatic mutation carriers for autosomal dominant Alzheimer's disease (ADAD) and the predictive value of seizures for mutation carrier status in cognitively asymptomatic first-degree relatives of ADAD patients. Seizure occurrence in the Dominantly Inherited Alzheimer Network observational study was correlated with mutation carrier status in cognitively asymptomatic subjects. Of 276 cognitively asymptomatic individuals, 11 (4%) had experienced seizures, and nine of these carried an ADAD mutation. Thus, in the Dominantly Inherited Alzheimer Network population, seizure frequency in mutation carriers was significantly higher than in noncarriers (p = 0.04), and the positive predictive value of seizures for the presence of a pathogenic mutation was 81.8%. Among cognitively asymptomatic ADAD family members, the occurrence of seizures increases the a priori risk of 50% mutation-positive status to about 80%. This finding suggests that ADAD mutations increase the risk of seizures.

Original languageEnglish (US)
Pages (from-to)18-23
Number of pages6
JournalNeurobiology of Aging
Volume76
DOIs
StatePublished - Apr 1 2019

Fingerprint

Alzheimer Disease
Seizures
Mutation
Mutation Rate
Observational Studies
Population

Keywords

  • Alzheimer's disease
  • Autosomal dominant
  • Dementia
  • Genetics
  • Positive predictive value
  • Seizures

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

Cite this

Seizures as an early symptom of autosomal dominant Alzheimer's disease. / Dominantly Inherited Alzheimer Network.

In: Neurobiology of Aging, Vol. 76, 01.04.2019, p. 18-23.

Research output: Contribution to journalArticle

Dominantly Inherited Alzheimer Network. / Seizures as an early symptom of autosomal dominant Alzheimer's disease. In: Neurobiology of Aging. 2019 ; Vol. 76. pp. 18-23.
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abstract = "Our objective was to assess the reported history of seizures in cognitively asymptomatic mutation carriers for autosomal dominant Alzheimer's disease (ADAD) and the predictive value of seizures for mutation carrier status in cognitively asymptomatic first-degree relatives of ADAD patients. Seizure occurrence in the Dominantly Inherited Alzheimer Network observational study was correlated with mutation carrier status in cognitively asymptomatic subjects. Of 276 cognitively asymptomatic individuals, 11 (4{\%}) had experienced seizures, and nine of these carried an ADAD mutation. Thus, in the Dominantly Inherited Alzheimer Network population, seizure frequency in mutation carriers was significantly higher than in noncarriers (p = 0.04), and the positive predictive value of seizures for the presence of a pathogenic mutation was 81.8{\%}. Among cognitively asymptomatic ADAD family members, the occurrence of seizures increases the a priori risk of 50{\%} mutation-positive status to about 80{\%}. This finding suggests that ADAD mutations increase the risk of seizures.",
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AU - Schofield, Peter R.

AU - Sperling, Reisa

AU - Jucker, Mathias

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AU - Paumier, Katrina

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N2 - Our objective was to assess the reported history of seizures in cognitively asymptomatic mutation carriers for autosomal dominant Alzheimer's disease (ADAD) and the predictive value of seizures for mutation carrier status in cognitively asymptomatic first-degree relatives of ADAD patients. Seizure occurrence in the Dominantly Inherited Alzheimer Network observational study was correlated with mutation carrier status in cognitively asymptomatic subjects. Of 276 cognitively asymptomatic individuals, 11 (4%) had experienced seizures, and nine of these carried an ADAD mutation. Thus, in the Dominantly Inherited Alzheimer Network population, seizure frequency in mutation carriers was significantly higher than in noncarriers (p = 0.04), and the positive predictive value of seizures for the presence of a pathogenic mutation was 81.8%. Among cognitively asymptomatic ADAD family members, the occurrence of seizures increases the a priori risk of 50% mutation-positive status to about 80%. This finding suggests that ADAD mutations increase the risk of seizures.

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